Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Transl Oncol. 2024 Jan;26(1):16-38. doi: 10.1007/s12094-023-03209-2. Epub 2023 May 13.
Recent studies have revealed the impact of microRNAs (miRNAs) in the carcinogenic process. miR-424 is a miRNA whose role in this process is being to be identified. Experiments in the ovarian cancer, cervical cancer, hepatocellular carcinoma, neuroblastoma, breast cancer, osteosarcoma, intrahepatic cholangiocarcinoma, prostate cancer, endometrial cancer, non-small cell lung cancer, hemangioma and gastric cancer have reported down-regulation of miR-424. On the other hand, this miRNA has been found to be up-regulated in melanoma, laryngeal and esophageal squamous cell carcinomas, glioma, multiple myeloma and thyroid cancer. Expression of this miRNA is regulated by methylation status of its promoter. Besides, LINC00641, CCAT2, PVT1, LIN00657, LINC00511 and NNT-AS1 are among lncRNAs that act as molecular sponges for miR-424, thus regulating its expression. Moreover, several members of SNHG family of lncRNAs have been found to regulate expression of miR-424. This miRNA is also involved in the regulation of E2F transcription factors. The current review aims at summarization of the role of miR-424 in the process of cancer evolution and its impact on clinical outcome of patients in order to find appropriate markers for malignancies.
最近的研究揭示了 microRNAs（miRNAs）在致癌过程中的作用。miR-424 是一种 miRNA，其在这一过程中的作用尚待确定。在卵巢癌、宫颈癌、肝细胞癌、神经母细胞瘤、乳腺癌、骨肉瘤、肝内胆管癌、前列腺癌、子宫内膜癌、非小细胞肺癌、血管瘤和胃癌的实验中，报道了 miR-424 的下调。另一方面，已经发现这种 miRNA 在黑色素瘤、喉癌和食管鳞状细胞癌、神经胶质瘤、多发性骨髓瘤和甲状腺癌中上调。该 miRNA 的表达受其启动子甲基化状态的调节。此外，LINC00641、CCAT2、PVT1、LIN00657、LINC00511 和 NNT-AS1 是作为 miR-424 分子海绵的 lncRNAs 之一，从而调节其表达。此外，已经发现 SNHG 家族的几个 lncRNAs 成员调节 miR-424 的表达。这种 miRNA 还参与 E2F 转录因子的调节。本综述旨在总结 miR-424 在癌症进化过程中的作用及其对患者临床结局的影响，以寻找恶性肿瘤的合适标志物。
