Hussein Abdelaziz, Ghonimy Abdallah, Jiang Hailong, Qin Guixin, El-Ashram Saeed, Hussein Saddam, Abd El-Razek Ibrahim, El-Afifi Tarek, Farouk Mohammed Hamdy
College of Animal Science and Technology Jilin Agricultural University Changchun China.
Jilin Provincial Key Lab of Animal Nutrition and Feed Science Jilin Agricultural University Changchun China.
Food Sci Nutr. 2023 Jan 27;11(5):2321-2335. doi: 10.1002/fsn3.3236. eCollection 2023 May.
Mushrooms possess antihyperglycemic effect on diabetic individuals due to their nonfibrous and fibrous bioactive compounds. This study aimed to reveal the effect of different types of mushrooms on plasma glucose level and gut microbiota composition in diabetic individuals. The effects of five different mushroom species (, GLM; , POM; , PCM; , LEM; or , HMM) on alloxan-induced diabetic rats were investigated in this study. The results indicated that LEM and HMM treatments showed lower plasma glucose levels. For the microbiota composition, , , , and were significantly affected by PCM and LEM treatments ( .05), while ACE, Shannon, and Simpson indexes were affected by HMM treatment ( .01). Simpson index was affected in positive control (C+) and POM groups. All these four indices were lower in GLM treatment ( .05). Dietary supplementation of mushrooms reduced plasma glucose level directly through mushrooms' bioactive compounds (agmatine, sphingosine, pyridoxine, linolenic, and alanine) and indirectly through stachyose (oligosaccharide) and gut microbiota modulation. In conclusion, LEM and HMM can be used as food additives to improve plasma glucose level and gut microbiome composition in diabetic individuals.
蘑菇因其非纤维和纤维生物活性化合物对糖尿病个体具有降血糖作用。本研究旨在揭示不同类型蘑菇对糖尿病个体血糖水平和肠道微生物群组成的影响。本研究调查了五种不同蘑菇品种（, GLM；, POM；, PCM；, LEM；或, HMM）对四氧嘧啶诱导的糖尿病大鼠的影响。结果表明，LEM和HMM处理组的血糖水平较低。对于微生物群组成，PCM和LEM处理显著影响了, ,, 和 （P <.05），而ACE、香农和辛普森指数受HMM处理影响（P <.01）。辛普森指数在阳性对照组（C+）和POM组中受到影响。在GLM处理中，所有这四个指数均较低（P <.05）。膳食补充蘑菇可通过蘑菇的生物活性化合物（胍丁胺、鞘氨醇、吡哆醇、亚麻酸和丙氨酸）直接降低血糖水平，并通过水苏糖（低聚糖）和肠道微生物群调节间接降低血糖水平。总之，LEM和HMM可作为食品添加剂用于改善糖尿病个体的血糖水平和肠道微生物群组成。
