Wang Zhen, Zhang Hui, Wang Li, Ma Zhen, Cui Yu'ang, Fu Haitian, Yu Chunjing
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University, Wuxi, China.
Front Oncol. 2023 Apr 27;13:1183405. doi: 10.3389/fonc.2023.1183405. eCollection 2023.
In the past 5 years, ferroptosis-associated cancer immunity has been attracted significant research interest.
This study was performed to identify and analyze the global output trend for ferroptosis in cancer immunity.
Relevant studies were retrieved from the Web of Science Core Collection on Feb 10, 2023. The VOSviewer and Histcite softwares were utilized to perform the visual bibliometric and deep mining analyses.
A total of 694 studies (530 articles (76.4%) and 164 (23.6%) review articles) were retrieved from the Web of Science Core Collection for visualization analyses. The top 3 key keywords were ferroptosis, prognosis and immunotherapy. The top 30 local citation score (LCS) authors were all collaborators of Zou Weiping. Deep mining of 51 nanoparticle-related articles showed that BIOMATERIALS was the most popular journal. The primary goal of gene signatures related to ferroptosis and cancer immunity was to establish prognostic predictions.
There has been a significant increase in ferroptosis-associated immune publications in the recent 3 years. The key research hotspots include mechanisms, prediction and therapeutic outcomes. The most influential article was from the Zou Weiping's group, which proposed that system xc-mediated ferroptosis is induced by CD8(+) T cell-secreted IFNγ after PD-L1 blockage for immunotherapy. The frontier of research in the field of ferroptosis-associated immune is the study on nanoparticle and gene signature The limitation of this bibliometric study is that publications on this topic are few.
在过去5年中，铁死亡相关的癌症免疫已引起了重大研究兴趣。
本研究旨在识别和分析癌症免疫中铁死亡的全球产出趋势。
于2023年2月10日从科学网核心合集检索相关研究。利用VOSviewer和Histcite软件进行可视化文献计量和深度挖掘分析。
从科学网核心合集中检索到694项研究（530篇文章（76.4%）和164篇综述文章（23.6%））用于可视化分析。前3个关键关键词是铁死亡、预后和免疫治疗。前30名本地引用得分（LCS）作者均为邹卫平的合作者。对51篇与纳米颗粒相关文章的深度挖掘表明，《生物材料》是最受欢迎的期刊。与铁死亡和癌症免疫相关的基因特征的主要目标是建立预后预测。
近3年铁死亡相关免疫方面的出版物显著增加。关键研究热点包括机制、预测和治疗结果。最具影响力的文章来自邹卫平团队，该文章提出在免疫治疗中，PD-L1阻断后，CD8(+)T细胞分泌的IFNγ可诱导系统xc介导的铁死亡。铁死亡相关免疫领域的研究前沿是纳米颗粒和基因特征研究。本文献计量研究的局限性在于关于该主题的出版物较少。
