Yuan Jing, Zhao Kankan, Tan Xiangfeng, Xue Ran, Zeng Yuan, Ratti Carlo, Trivedi Pankaj
Microbiome Network and Department of Agricultural Biology, Colorado State University, Fort Collins, CO 80524, USA; Senseable City Lab, Department of Urban Studies and Planning, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Institute of Soil and Water Resources and Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
Trends Biotechnol. 2023 Oct;41(10):1227-1236. doi: 10.1016/j.tibtech.2023.04.007. Epub 2023 May 13.
Synthetic microbial community (SynCom) biosensors are a promising technology for detecting and responding to environmental cues and target molecules. SynCom biosensors use engineered microorganisms to create a more complex and diverse sensing system, enabling them to respond to stimuli with enhanced sensitivity and accuracy. Here, we give a definition of SynCom biosensors, outline their construction workflow, and discuss current biosensing technology. We also highlight the challenges and future for developing and optimizing SynCom biosensors and the potential applications in agriculture and food management, biotherapeutic development, home sensing, urban and environmental monitoring, and the One Health foundation. We believe SynCom biosensors could be used in a real-time and remote-controlled manner to sense the chaos of constantly dynamic environments.
合成微生物群落（SynCom）生物传感器是一种用于检测环境线索和目标分子并做出响应的很有前景的技术。SynCom生物传感器利用经过工程改造的微生物来创建一个更加复杂和多样的传感系统，使其能够以更高的灵敏度和准确性对刺激做出反应。在此，我们给出SynCom生物传感器的定义，概述其构建工作流程，并讨论当前的生物传感技术。我们还强调了开发和优化SynCom生物传感器所面临的挑战与未来发展方向，以及其在农业和食品管理、生物治疗开发、家庭传感、城市和环境监测以及“同一健康”基础等方面的潜在应用。我们相信SynCom生物传感器能够以实时和远程控制的方式用于感知不断动态变化的环境中的各种情况。
