Lyoussi Badiaa, Laaroussi Hassan, Cherkaoui-Tangi Khadija, Hano Christophe, Morel Nicole
Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Department of Biology, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdallah University, 30000 Fez, Morocco.
Secteur des Sciences de la Santé, Université Catholique de Louvain, Bruxelles, Belgium.
Evid Based Complement Alternat Med. 2023 May 11;2023:3081102. doi: 10.1155/2023/3081102. eCollection 2023.
is used in traditional medicine for the prevention and self-treatment of a variety of illnesses, including diabetes mellitus, obesity, and hypertension. The present study aims to investigate the , , and hypoglycemic and hypotensive effects of the lyophilized aqueous extract of . seeds (CV) on submitted to hypercaloric diet and physical inactivity (HCD/PI) for 12 weeks. This diet induces a type 2 diabetes/metabolic syndrome phenotype with hypertension. Furthermore, HCD/PI decreased aorta contraction due to noradrenaline, enhanced L-arginine, and depressed insulin-evoked relaxation, while the relaxing effects of the NO donor SNAP and of diazoxide were unchanged. experiments showed that the oral administration of the CV extract (50 mg/kg b.wt) for 3 consecutive weeks significantly attenuated the development of type 2 diabetes, obesity, dyslipidemia, and hypertension. These effects may involve the improvement of lipid metabolism, insulin sensitivity, systolic arterial pressure, and urine output. Additionally, and investigations revealed that CV treatment improved vascular contraction to noradrenaline, induced a slight aorta relaxation in response to carbachol, increased the vasorelaxation effect evoked by insulin, and depressed the L-arginine evoked relaxation. However, CV did not change the endothelium-independent vasorelaxation response evoked by SNAP or diazoxide. Hence, the present study provides useful information and supports the traditional use of CV in the prevention and self-treatment of numerous ailments. Overall, it can be concluded that . seed extracts might be useful in the management of type 2 diabetes and hypertension.
在传统医学中用于预防和自我治疗多种疾病，包括糖尿病、肥胖症和高血压。本研究旨在调查[具体植物名称]种子（CV）冻干水提取物对连续12周接受高热量饮食和缺乏身体活动（HCD/PI）的[实验对象]的降糖、降压作用。这种饮食会诱发伴有高血压的2型糖尿病/代谢综合征表型。此外，HCD/PI降低了去甲肾上腺素引起的主动脉收缩，增强了L-精氨酸，并抑制了胰岛素诱发的舒张，而一氧化氮供体SNAP和二氮嗪的舒张作用未改变。实验表明，连续3周口服CV提取物（50mg/kg体重）可显著减轻2型糖尿病、肥胖症、血脂异常和高血压的发展。这些作用可能涉及脂质代谢、胰岛素敏感性、收缩压和尿量的改善。此外，[具体实验]研究表明，CV治疗改善了对去甲肾上腺素的血管收缩反应，对卡巴胆碱引起的主动脉有轻微舒张作用，增强了胰岛素诱发的血管舒张作用，并抑制了L-精氨酸诱发的舒张。然而，CV并未改变SNAP或二氮嗪引起的内皮依赖性血管舒张反应。因此，本研究提供了有用的信息，并支持了CV在预防和自我治疗多种疾病中的传统用途。总体而言，可以得出结论，[具体植物名称]种子提取物可能对2型糖尿病和高血压的管理有用。
