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CRISPR-free, strand-selective mitochondrial DNA base editing using a nickase.

出版信息

Nat Biotechnol. 2024 Mar;42(3):392-393. doi: 10.1038/s41587-023-01820-w.

DOI:10.1038/s41587-023-01820-w

PMID:37217753

Abstract

摘要

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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.

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Nat Biotechnol. 2024 Mar;42(3):392-393. doi: 10.1038/s41587-023-01820-w.

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Nat Biotechnol. 2024 Mar;42(3):498-509. doi: 10.1038/s41587-023-01791-y. Epub 2023 May 22.

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Mitochondrial base editor induces substantial nuclear off-target mutations.

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Nature. 2020 Jul;583(7817):631-637. doi: 10.1038/s41586-020-2477-4. Epub 2020 Jul 8.

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Mitochondrial disorders as windows into an ancient organelle.

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