i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; Cancer Drug Resistance Group, IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Portugal, 4200-135 Porto, Portugal; Department of Biological Sciences, FFUP - Faculty of Pharmacy of the University of Porto, Porto, Portugal.
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; Cancer Drug Resistance Group, IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Portugal, 4200-135 Porto, Portugal.
Cytokine Growth Factor Rev. 2023 Oct;73:150-162. doi: 10.1016/j.cytogfr.2023.05.001. Epub 2023 May 14.
In order to adapt to a higher proliferative rate and an increased demand for energy sources, cancer cells rewire their metabolic pathways, a process currently recognized as a hallmark of cancer. Even though the metabolism of glucose is perhaps the most discussed metabolic shift in cancer, lipid metabolic alterations have been recently recognized as relevant players in the growth and proliferation of cancer cells. Importantly, some of these metabolic alterations are reported to induce a drug resistant phenotype in cancer cells. The acquisition of drug resistance traits severely hinders cancer treatment, being currently considered one of the major challenges of the oncological field. Evidence suggests that Extracellular Vesicles (EVs), which play a crucial role in intercellular communication, may act as facilitators of tumour progression, survival and drug resistance by modulating several aspects involved in the metabolism of cancer cells. This review aims to gather and discuss relevant data regarding metabolic reprograming in cancer, particularly involving the glycolytic and lipid alterations, focusing on its influence on drug resistance and highlighting the relevance of EVs as intercellular mediators of this process.
为了适应更高的增殖率和对能源的需求增加，癌细胞重新布线其代谢途径，这一过程目前被认为是癌症的一个标志。尽管葡萄糖代谢可能是癌症中讨论最多的代谢转变，但最近已经认识到脂代谢改变是癌细胞生长和增殖的相关因素。重要的是，据报道，其中一些代谢改变会诱导癌细胞产生耐药表型。耐药性特征的获得严重阻碍了癌症的治疗，目前被认为是肿瘤领域的主要挑战之一。有证据表明，细胞外囊泡 (EVs) 在细胞间通讯中发挥着至关重要的作用，通过调节癌细胞代谢涉及的几个方面，可能作为肿瘤进展、存活和耐药性的促进剂。这篇综述旨在收集和讨论有关癌症代谢重编程的相关数据，特别是涉及糖酵解和脂质改变的方面，重点关注其对耐药性的影响，并强调 EVs 作为细胞间代谢过程中介的相关性。
