Schumacher M J, Cota K A, Taussig L M
J Allergy Clin Immunol. 1986 Jul;78(1 Pt 1):30-5. doi: 10.1016/0091-6749(86)90111-9.
Nasal deposition of allergen or histamine could cause bronchoconstriction in subjects with asthma by a reflex mechanism. To investigate this possibility, six atopic subjects with stable asthma and five normal control subjects were studied by nasal-challenge testing with saline, Bermuda grass-pollen allergen, and histamine on paper disks. Challenges were done on 3 separate days by use of a double-blind, randomized trial design. Fivefold serial dilutions were used to determine threshold doses for provocation of at least a twofold increase in the postsaline nasal airway resistance. No patient developed cough or wheezing or required treatment at the end of the nasal-challenge tests, even when persistent sneezing was provoked or in the subject who had a dual nasal response to nasal challenge. In spite of changes in nasal airway resistance that generally conformed to expectations, there were no significant effects of nasal challenge on lung function, including forced expiratory flow rates, vital capacity, residual volume, and partial expiratory flow-volume curves.
变应原或组胺的鼻腔沉积可通过反射机制导致哮喘患者出现支气管收缩。为研究这种可能性，对6名病情稳定的特应性哮喘患者和5名正常对照者进行了研究，采用在纸片上滴注生理盐水、百慕大草花粉变应原和组胺的鼻腔激发试验。通过双盲随机试验设计，在3个不同日期进行激发试验。采用五倍系列稀释法确定激发至少使鼻腔气道阻力在滴注生理盐水后增加两倍的阈值剂量。即使诱发了持续性打喷嚏或对鼻腔激发试验有双重鼻腔反应的受试者，在鼻腔激发试验结束时，也没有患者出现咳嗽或喘息，或需要治疗。尽管鼻腔气道阻力的变化总体上符合预期，但鼻腔激发试验对肺功能没有显著影响，包括用力呼气流速、肺活量、残气量和部分呼气流量-容积曲线。
