4至17岁健康受试者呼出一氧化氮的测量。

Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years.

作者信息

Buchvald Frederik, Baraldi Eugenio, Carraro Silvia, Gaston Benjamin, De Jongste Johan, Pijnenburg Mariëlle W H, Silkoff Philip E, Bisgaard Hans

机构信息

The Copenhagen Studies of Asthma in Childhood Research Clinic, Copenhagen University Hospital, Gentofte, Denmark.

出版信息

J Allergy Clin Immunol. 2005 Jun;115(6):1130-6. doi: 10.1016/j.jaci.2005.03.020.

DOI:10.1016/j.jaci.2005.03.020

PMID:15940124

Abstract

BACKGROUND

Fractional exhaled nitric oxide (FE NO ) is used in monitoring of asthma.

OBJECTIVES

The aim of this multicenter study was to establish normal values of FE NO and assess feasibility in children with a standardized method and equipment approved for clinical use.

METHODS

FE NO was measured in healthy subjects of 4 to 17 years according to American Thoracic Society guidelines (single breath online, exhalation flow 50 mL/s) with a chemiluminescence analyzer (NIOX Exhaled Nitric Oxide Monitoring System, Aerocrine, Sweden) in 3 European and 2 US centers. Each child performed 3 acceptable nitric oxide measurements within 6 attempts and completed an extended International Study of Asthma and Allergy in Children questionnaire.

RESULTS

Measurement of FE NO was attempted in 522 children. Four hundred five children completed the study according to the protocol. Geometric mean FE NO in 405 children was 9.7 ppb, and the upper 95% confidence limit was 25.2 ppb. FE NO increased significantly with age, and higher FE NO was seen in children with self-reported rhinitis/conjunctivitis or hay fever. The success rate was age-dependent and improved from 40% in the children 4 years old to almost 100% from the age of 10 years. The repeatability of 3 approved measurements was 1.6 ppb (95% CI, 1.49-1.64 ppb).

CONCLUSION

FE NO in healthy children is below 15 to 25 ppb depending on age and self-reported atopy. Measurement of FE NO by NIOX is simple and safe and has a good repeatability. Feasibility depends on age and may be difficult in the preschool child.

摘要

背景

呼出一氧化氮分数（FE NO）用于哮喘监测。

目的

这项多中心研究的目的是建立FE NO的正常值，并使用经临床批准的标准化方法和设备评估其在儿童中的可行性。

方法

在欧洲3个中心和美国2个中心，根据美国胸科学会指南（单次呼气在线，呼气流量50 mL/s），使用化学发光分析仪（NIOX呼出一氧化氮监测系统，瑞典Aerocrine公司）对4至17岁的健康受试者进行FE NO测量。每个儿童在6次尝试内完成3次可接受的一氧化氮测量，并完成扩展的儿童哮喘和过敏国际研究问卷。

结果

对522名儿童进行了FE NO测量。405名儿童按照方案完成了研究。405名儿童的FE NO几何平均值为9.7 ppb，95%置信上限为25.2 ppb。FE NO随年龄显著增加，自我报告有鼻炎/结膜炎或花粉热的儿童FE NO更高。成功率与年龄有关，4岁儿童为40%，10岁及以上儿童几乎达到100%。3次批准测量的重复性为1.6 ppb（95%CI，1.49 - 1.64 ppb）。