Costa D L, Lehmann J R, Harold W M, Drew R T
Lab Anim Sci. 1986 Jun;36(3):256-61.
A fiberoptic laryngoscope which allows direct visualization of the deep pharynx and epiglottis has been developed for transoral tracheal intubation of small laboratory mammals. The device has been employed in the intubation and instillation of a variety of substances into the lungs of rats, and with minor modification, has had similar application in mice, hamsters, and guinea pigs. The simplicity and ease of handling of the laryngoscope permits one person to intubate large numbers of enflurane anesthetized animals either on an open counter top or in a glove-box, as may be required for administration of carcinogenic materials. Instillation of 7Be-labeled carbon particles into the lungs of mice, hamsters, rats, and guinea pigs resulted in reasonably consistent interlobal distribution of particles for each test animal species with minimal tracheal deposition. However, actual lung tissue doses of carbon exhibited some species dependence.
一种用于小型实验哺乳动物经口气管插管的纤维喉镜已被开发出来，它能直接观察下咽和会厌。该装置已用于给大鼠肺部插管并注入各种物质，稍作修改后，也已在小鼠、仓鼠和豚鼠中得到类似应用。喉镜操作简单、易于使用，可让一人在开放的台面上或在手套箱中给大量接受恩氟烷麻醉的动物插管，这对于给予致癌物质可能是必要的。将7Be标记的碳颗粒注入小鼠、仓鼠、大鼠和豚鼠的肺部后，每种受试动物物种的颗粒在肺叶间分布相当一致，气管沉积最少。然而，碳在实际肺组织中的剂量表现出一定的物种依赖性。
