Khalikova Daria, An'kov Sergey, Zhukova Nataliya, Tolstikova Tatyana, Popov Sergey, Saiko Anastasia
Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science, 9 Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
Pharmaceuticals (Basel). 2023 May 19;16(5):768. doi: 10.3390/ph16050768.
This study was conducted to evaluate the effects of long-term administration of a new herbal composition of leuzea and cranberry meal extracts at a dose of 70:500 mg/kg in healthy and pathological mice. After 4 weeks of daily composition administration to healthy CD-1 mice and C57BL/6 mice with diet-induced metabolic syndrome, oral glucose tolerance test (OGTT), serum biochemical examination and histology of internal organs were performed. Additionally, histological examination of white and brown adipose tissue was performed to evaluate the ability of the composition to prevent abdominal obesity in C57BL/6Ay (agouti yellow) mice. The results showed that the composition increased tissue sensitivity to glucose in healthy CD-1 mice; at the same time, it did not worsen the course of pathological processes in pathological mice. In both cases, the application of the developed composition was safe and contributed to the restoration of metabolic parameters.
本研究旨在评估长期给予健康小鼠和病理小鼠剂量为70:500 mg/kg的新的列当和酸果蔓粉提取物草药组合物的效果。在对健康的CD-1小鼠和患有饮食诱导代谢综合征的C57BL/6小鼠每日给予该组合物4周后，进行了口服葡萄糖耐量试验（OGTT）、血清生化检查和内脏组织学检查。此外，还对白色和棕色脂肪组织进行了组织学检查，以评估该组合物预防C57BL/6Ay（刺豚鼠黄色）小鼠腹部肥胖的能力。结果表明，该组合物提高了健康CD-1小鼠组织对葡萄糖的敏感性；同时，它并未使病理小鼠的病理过程恶化。在这两种情况下，所开发的组合物的应用都是安全的，并有助于代谢参数的恢复。
