Neurology Department, Trás-os-Montes and Alto Douro Hospital Center, Vila Real, Portugal.
Neurology Department, Porto Hospital and University Center, Porto, Portugal.
Perm J. 2023 Sep 15;27(3):14-21. doi: 10.7812/TPP/22.171. Epub 2023 May 29.
Introduction Neurological manifestations are frequent after acquiring COVID-19 and may persist long-term as part of post-COVID-19 syndrome. Cognitive impairment, chronic fatigue, sleep disturbances, and headache complaints are the most reported neurological features. During the COVID-19 pandemic, health care workers were particularly vulnerable due to the high workload and levels of stress associated with this period, but acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may also contribute. The authors aimed to evaluate the neurological involvement of acquiring SARS-CoV-2 in a population of hospital health care workers and its impact on their personal and professional lives. Methods A sample of health care workers who did and did not acquire SARS-CoV-2 matched by age and sociodemographic variables was studied. Through an online questionnaire, data were collected regarding the symptoms in the acute phase of the disease (for those who acquired it) and for all in the last 6 months of the study period. Proportion of neurological complaints were compared between groups, adjusting for age, sex, and professional class (using a rate ratio (RR)). Results This study included 326 participants (174 cases and 152 controls). The mean age (standard deviation) was 39.7 (10.2) years, and the female:male ratio was 3:1. Headache and cognitive complaints were the most prevalent neurological complaints in the last 6 months of the study period. The health care workers who acquired SARS-CoV-2 were more likely to report headache and cognitive complaints than the control group (RR = 1.51, 95% confidence interval = 1.17-1.9 and RR = 2.02, 95% confidence interval = 1.53-2.65, respectively). Conclusion In a population of health care workers, those who acquired SARS-CoV-2 were more likely to have long-term cognitive complaints and persistent headaches.
介绍 在感染 COVID-19 后，神经系统表现较为常见，并且可能作为 COVID-19 后综合征的一部分长期存在。认知障碍、慢性疲劳、睡眠障碍和头痛是最常见的神经系统特征。在 COVID-19 大流行期间，医护人员由于工作量大且压力水平高而特别容易受到影响，但感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）也可能导致这种情况。作者旨在评估感染 SARS-CoV-2 的医护人员人群中的神经系统受累情况及其对他们个人和职业生活的影响。
方法 研究纳入了年龄和社会人口统计学变量相匹配的感染 SARS-CoV-2 和未感染 SARS-CoV-2 的医护人员样本。通过在线问卷收集了急性疾病阶段（对于感染 SARS-CoV-2 的人员）和研究期间最后 6 个月的数据。比较了两组之间的神经系统投诉比例，通过年龄、性别和职业级别进行调整（使用率比（RR））。
结果 这项研究纳入了 326 名参与者（174 例病例和 152 例对照）。平均年龄（标准差）为 39.7（10.2）岁，女性与男性比例为 3:1。头痛和认知投诉是研究期间最后 6 个月最常见的神经系统投诉。感染 SARS-CoV-2 的医护人员比对照组更有可能报告头痛和认知投诉（RR=1.51，95%置信区间为 1.17-1.9；RR=2.02，95%置信区间为 1.53-2.65）。
结论 在医护人员人群中，感染 SARS-CoV-2 的人群更有可能出现长期认知投诉和持续性头痛。
