Duffy P E, Graf L, Huang Y Y, Rapport M M
J Neurol Sci. 1979 Feb;40(2-3):133-46. doi: 10.1016/0022-510x(79)90199-0.
Glial fibrillary acidic protein (GFAP) was studied in ependymomas by the three-step immunoperoxidase method and compared to results in astrocytomas and normal tissues. An order of reactivity for GFAP is presented. Diagnostic criteria, based on GFAP content, are proposed. In ependymomas GFAP-positive cells give rise to only some of the tumor cells, usually those forming tubules and perivascular arrangements. It is hypothesized that the same GFAP-positive cells may form tubules at their luminal poles and may produce perivascular arrangements at their other poles. The aberrant regulation associated with neoplastic transformation in glia is often, but not always, reflected in increased GFAP content. In both astrocytes and ependymal cells GFAP may have a similar function since in both cells the increase in GFAP appears to be related to the development of fibrillary processes.
采用三步免疫过氧化物酶法对室管膜瘤中的胶质纤维酸性蛋白（GFAP）进行了研究，并与星形细胞瘤和正常组织的研究结果进行了比较。给出了GFAP的反应性顺序。提出了基于GFAP含量的诊断标准。在室管膜瘤中，GFAP阳性细胞仅产生部分肿瘤细胞，通常是那些形成小管和血管周围排列的细胞。据推测，相同的GFAP阳性细胞可能在其管腔极形成小管，并在其另一极产生血管周围排列。与胶质细胞肿瘤转化相关的异常调节通常（但并非总是）反映在GFAP含量增加上。在星形胶质细胞和室管膜细胞中，GFAP可能具有相似的功能，因为在这两种细胞中，GFAP的增加似乎都与纤维状突起的发育有关。
