Rasmussen S, Bock E, Warecka K, Althage G
Br J Cancer. 1980 Jan;41(1):113-6. doi: 10.1038/bjc.1980.12.
The glial fibrillary acidic protein (GFA) content of 58 human brain tumours was determined by quantitative immunoelectrophoresis, using monospecific antibody against GFA. Astrocytomas, glioblastomas, oligodendrogliomas, spongioblastomas, ependymomas and medulloblastomas contained relatively high amounts of GFA, up to 85 times the concentration in parietal grey substance of normal human brain. GFA was not found in neurinomas, meningiomas, adenomas of the hypophysis, or in a single case of metastasis of adenocarcinoma. Non-glial tumours of craniopharyngioma and haemangioblastoma were infiltrated by reactive astroglia and showed considerable amounts of GFA.
采用抗胶质纤维酸性蛋白（GFA）的单特异性抗体，通过定量免疫电泳法测定了58例人脑肿瘤中的GFA含量。星形细胞瘤、胶质母细胞瘤、少突胶质细胞瘤、成胶质细胞瘤、室管膜瘤和髓母细胞瘤含有相对大量的GFA，最高可达正常人大脑顶叶灰质浓度的85倍。在神经鞘瘤、脑膜瘤、垂体腺瘤或1例腺癌转移病例中未发现GFA。颅咽管瘤和血管母细胞瘤等非胶质肿瘤被反应性星形胶质细胞浸润，并显示出大量的GFA。
