人脑肿瘤中胶质纤维酸性蛋白的定量分析。
Quantitation of glial fibrillary acidic protein in human brain tumours.
作者信息
Rasmussen S, Bock E, Warecka K, Althage G
出版信息
Br J Cancer. 1980 Jan;41(1):113-6. doi: 10.1038/bjc.1980.12.
Abstract
The glial fibrillary acidic protein (GFA) content of 58 human brain tumours was determined by quantitative immunoelectrophoresis, using monospecific antibody against GFA. Astrocytomas, glioblastomas, oligodendrogliomas, spongioblastomas, ependymomas and medulloblastomas contained relatively high amounts of GFA, up to 85 times the concentration in parietal grey substance of normal human brain. GFA was not found in neurinomas, meningiomas, adenomas of the hypophysis, or in a single case of metastasis of adenocarcinoma. Non-glial tumours of craniopharyngioma and haemangioblastoma were infiltrated by reactive astroglia and showed considerable amounts of GFA.
摘要
采用抗胶质纤维酸性蛋白（GFA）的单特异性抗体，通过定量免疫电泳法测定了58例人脑肿瘤中的GFA含量。星形细胞瘤、胶质母细胞瘤、少突胶质细胞瘤、成胶质细胞瘤、室管膜瘤和髓母细胞瘤含有相对大量的GFA，最高可达正常人大脑顶叶灰质浓度的85倍。在神经鞘瘤、脑膜瘤、垂体腺瘤或1例腺癌转移病例中未发现GFA。颅咽管瘤和血管母细胞瘤等非胶质肿瘤被反应性星形胶质细胞浸润，并显示出大量的GFA。
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本文引用的文献
1
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Brain Res. 1971 May 7;28(2):351-4. doi: 10.1016/0006-8993(71)90668-8.
2
Immunological study of the glial fibrillary acidic protein.胶质纤维酸性蛋白的免疫学研究
Brain Res. 1972 Feb 11;37(1):81-9. doi: 10.1016/0006-8993(72)90347-2.
3
Astrocyte-specific protein and radial glia in the cerebral cortex of newborn rat.新生大鼠大脑皮层中的星形胶质细胞特异性蛋白和放射状胶质细胞
Nature. 1974 Nov 1;252(5478):55-6. doi: 10.1038/252055a0.
4
Immunochemical and immunofluorescence studies of the glial fibrillary acidic protein in vertebrates.脊椎动物中胶质纤维酸性蛋白的免疫化学和免疫荧光研究。
Brain Res. 1973 Oct 26;61:279-93. doi: 10.1016/0006-8993(73)90533-7.
5
Immunization, isolation of immunoglobulins, estimation of antibody titre.免疫接种、免疫球蛋白的分离、抗体滴度的测定。
Scand J Immunol Suppl. 1973;1:161-4. doi: 10.1111/j.1365-3083.1973.tb03798.x.
6
Glial fibrillary acidic protein in human gliomas.人类胶质瘤中的胶质纤维酸性蛋白
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7
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