Department of Ophthalmology, Shanghai General Hospital, Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
National Clinical Research Center for Eye Diseases, Shanghai, China.
BMC Ophthalmol. 2023 May 31;23(1):243. doi: 10.1186/s12886-023-02998-y.
Cataract is the primary cause of blindness globally, and surgery offers the only method by which to remove cataracts. We aimed to examine whether previous cataract surgery is associated with cognitive function.
Our study included 13,824 participants. Data from the baseline of the China Health and Retirement Longitudinal Study (CHARLS) were used. The participants were categorized into two groups: with and without previous cataract surgery. Weighted multiple linear regression was used to obtain the β and 95% confidence intervals (CI).
The participants who had previous cataract surgery (n = 261) scored lower in cognition, including both memory and mental state, than those without previous cataract surgery. After adjusting for socioeconomic factors and metabolic measures, a negative association was evident between previous cataract surgery and cognition (β = -0.647, 95% CI: -1.244, - 0.049). Furthermore, the participants who were older and female demonstrated a decline in cognition, while living in cities and having higher levels education were associated with higher cognition.
Better cognitive function was associated with less previous cataract surgery or cataract occurrence. This suggests that a period of vision loss due to cataract leads to cognitive decline, however further studies are need to dissect the impact of vision loss and cataract surgery on cognitive decline.
白内障是全球致盲的主要原因，手术是唯一去除白内障的方法。我们旨在研究既往白内障手术是否与认知功能有关。
我们的研究纳入了 13824 名参与者。使用中国健康与养老追踪调查（CHARLS）基线数据。参与者分为两组：有既往白内障手术史组和无既往白内障手术史组。采用加权多重线性回归分析获得β值和 95%置信区间（CI）。
与无既往白内障手术史者相比，行过既往白内障手术者（n=261）的认知功能，包括记忆力和精神状态，得分更低。在校正社会经济因素和代谢指标后，既往白内障手术与认知功能之间存在负相关（β=-0.647，95%CI：-1.244，-0.049）。此外，年龄较大和女性的认知功能下降，而居住在城市和受教育程度较高与认知功能较高相关。
更好的认知功能与较少的既往白内障手术或白内障发生有关。这表明白内障引起的一段时间视力丧失会导致认知能力下降，但需要进一步研究来剖析视力丧失和白内障手术对认知能力下降的影响。
