[中国粗榧茎叶中的木脂素（Ⅱ）]

[Lignans from stems and leaves of Cephalotaxus fortunei (Ⅱ)].

作者信息

Tian Jia-Mei, Yuan Yi-Zhen, Wang Jing-Li, Li Da-Hong, Bai Jiao, Hua Hui-Ming

机构信息

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Chinese Materia Medica, Shenyang Pharmaceutical University Shenyang 117004, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2023 Apr;48(7):1892-1898. doi: 10.19540/j.cnki.cjcmm.20220928.201.

DOI:10.19540/j.cnki.cjcmm.20220928.201

PMID:37282965

Abstract

The present study aimed to explore the chemical constituents from the stems and leaves of Cephalotaxus fortunei. Seven lignans were isolated from the 75% ethanol extract of C. fortunei by various chromatographic methods, including silica gel, ODS column chromatography, and HPLC. The structures of the isolated compounds were elucidated according to physicochemical properties and spectral data. Compound 1 is a new lignan named cephalignan A. The known compounds were identified as 8-hydroxy-conidendrine(2), isolariciresinol(3), leptolepisol D(4), diarctigenin(5), dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucopyranoside(6), and dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(7). Compounds 2 and 5 were isolated from the Cephalotaxus plant for the first time.

摘要

本研究旨在探索中国粗榧茎和叶中的化学成分。通过硅胶、ODS柱色谱和高效液相色谱等多种色谱方法，从中国粗榧75%乙醇提取物中分离出7种木脂素。根据理化性质和光谱数据阐明了分离得到的化合物的结构。化合物1是一种新的木脂素，命名为中国粗榧木脂素A。已知化合物分别鉴定为8-羟基-去甲三尖杉碱(2)、异落叶松脂醇(3)、薄鳞木脂素D(4)、二对羟基桂皮酸(5)、二氢去氢双松柏醇9'-O-β-D-吡喃葡萄糖苷(6)和二氢去氢双松柏醇4-O-β-D-吡喃葡萄糖苷(7)。化合物2和5首次从中国粗榧植物中分离得到。