Instituto de Química de São Carlos, Universidade de São Paulo, CEP 13560-970, São Carlos, SP, Brazil.
Instituto de Física de São Carlos, Universidade de São Paulo, CEP 13563-120, São Carlos, SP, Brazil.
J Nat Prod. 2023 Jun 23;86(6):1476-1486. doi: 10.1021/acs.jnatprod.3c00175. Epub 2023 Jun 8.
Bioassay-guided investigation of the EtOAc-soluble extract of a culture of the marine-derived fungus sp. M16 led to the isolation of seven new polyketide- and terpenoid-derived metabolites (, , -), along with known polyketides (, -). Structures of compounds , , and - were established by analysis of spectroscopic data. Absolute configurations of compounds , , , , , and were determined by the comparison of experimental ECD spectra with calculated CD data. Compound exhibited moderate antiplasmodial activity against both chloroquine-sensitive and -resistant strains of .
生物活性导向分离技术研究海洋来源真菌 M16 的 EtOAc 可溶部分，得到了 7 个新的聚酮和萜烯类化合物（、、-），以及已知的聚酮类化合物（、-）。通过分析光谱数据确定了化合物、、和-的结构。通过比较实验 ECD 光谱与计算 CD 数据确定了化合物、、、、、和 的绝对构型。化合物 对氯喹敏感和耐药的疟原虫均表现出中等的抗疟活性。
