Improve the performance of CT-based pneumonia classification via source data reweighting.

Pneumonia is a life-threatening disease. Computer tomography (CT) imaging is broadly used for diagnosing pneumonia. To assist radiologists in accurately and efficiently detecting pneumonia from CT scans, many deep learning methods have been developed. These methods require large amounts of annotated CT scans, which are difficult to obtain due to privacy concerns and high annotation costs. To address this problem, we develop a three-level optimization based method which leverages CT data from a source domain to mitigate the lack of labeled CT scans in a target domain. Our method automatically identifies and downweights low-quality source CT data examples which are noisy or have large domain discrepancy with target data, by minimizing the validation loss of a target model trained on reweighted source data. On a target dataset with 2218 CT scans and a source dataset with 349 CT images, our method achieves an F1 score of 91.8% in detecting pneumonia and an F1 score of 92.4% in detecting other types of pneumonia, which are significantly better than those achieved by state-of-the-art baseline methods.