Lin Yang, Peng Shunlin
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Ear Nose Throat J. 2023 Jun 9:1455613231180031. doi: 10.1177/01455613231180031.
Laryngopharyngeal reflux (LPR) is a complex syndrome characterized by the reflux of gastroduodenal contents into the pharynx or larynx, resulting in a range of symptoms, including chronic cough, throat clearing, pain, dysphagia, hoarseness, and dysphonia. Despite the lack of a gold standard for diagnosis or treatment, various strategies have been proposed to manage LPR. However, the effectiveness of these treatments is compromised by the lack of a uniform treatment protocol, which places a burden on patients, physicians, and the healthcare system. This study aims to systematically review the treatments of LPR and provide updated and useful clinical information to clinical physicians. The literature with an emphasis on LPR and related keywords is searched and reviewed in PubMed. Treatment of LPR includes health education, lifestyle modification, dietary changes, medications, and surgery, as well as the emergence of a novel treatment method involving external upper esophageal sphincter compression devices. Currently, medication is the main treatment, supplemented with lifestyle and dietary changes, but there is still a lack of effective means for patients with drug-resistant or intolerant LPR. More high-quality and rigorous trials must continue to be conducted to determine the best treatment options and find novel treatments. Taking into account the complexity of LPR, this study proposes a simple algorithm to help clinicians with the initial management of this disease.
喉咽反流（LPR）是一种复杂的综合征，其特征为胃十二指肠内容物反流至咽部或喉部，导致一系列症状，包括慢性咳嗽、清嗓、疼痛、吞咽困难、声音嘶哑和发音障碍。尽管缺乏诊断或治疗的金标准，但已提出了各种管理LPR的策略。然而，这些治疗的有效性因缺乏统一的治疗方案而受到影响，这给患者、医生和医疗系统带来了负担。本研究旨在系统回顾LPR的治疗方法，并为临床医生提供最新且有用的临床信息。在PubMed中检索并回顾了侧重于LPR及相关关键词的文献。LPR的治疗包括健康教育、生活方式改变、饮食调整、药物治疗和手术，以及一种涉及外部食管上括约肌压迫装置的新型治疗方法的出现。目前，药物治疗是主要治疗方法，并辅以生活方式和饮食调整，但对于耐药或不耐受LPR的患者仍缺乏有效的治疗手段。必须继续开展更多高质量、严格的试验，以确定最佳治疗方案并找到新的治疗方法。考虑到LPR的复杂性，本研究提出了一种简单的算法，以帮助临床医生对该疾病进行初始管理。
