Bivolaru Sorin, Constantin Ancuta, Vlase Constantin Marinel, Gutu Cristian
Clinical Medical Department, University of Medicine and Pharmacy Carol Davila Bucharest, 030167 Bucharest, Romania.
Department of Cardio-Thoracic Pathology, Carol Davila University of Medicine and Pharmacy Bucharest, 030167 Bucharest, Romania.
Healthcare (Basel). 2023 May 30;11(11):1606. doi: 10.3390/healthcare11111606.
Inhaler therapy plays a crucial role in controlling respiratory symptoms in patients with chronic obstructive pulmonary disease (COPD). Incorrect or partially correct use of inhaler devices causes many chronic obstructive pulmonary disease (COPD) patients to continue to have respiratory symptoms due to poor drug deposition in the airways as a result of poor inhaler technique, leading to increased healthcare costs due to exacerbations and multiple emergency room presentations. Choosing the right inhaler device for each individual patient is a bigger challenge for doctors and chronic obstructive pulmonary disease (COPD) patients. The type of inhaler device and the correct inhaler technique depends on the control of symptoms in chronic obstructive pulmonary disease (COPD). Physicians treating patients with chronic obstructive pulmonary disease (COPD) play a central role in educating patients about the correct use of inhalation devices. The steps for the correct use of inhalation devices should be taught to patients by doctors in the presence of the family so that if the patient has difficulties handling the device correctly, the family can support them.
Our analysis included 200 subjects divided into two groups-recommended group (RG) and chosen group (CG)-and aimed primarily to identify the behaviour of chronic obstructive pulmonary disease (COPD) patients when faced with deciding which type of inhaler device is most suitable for them. The two groups were monitored three times during the 12-month follow-up period. Monitoring required the physical presence of the patient at the investigating physician's office. The study included patients who were smokers, ex-smokers, and/or with significant exposure to occupational pollutants, aged over 40 years diagnosed with chronic obstructive pulmonary disease (COPD), risk group B and C according to the GOLD guideline staging, and on inhaled ICS+LABA treatment, although they had an indication for LAMA+LABA dual bronchodilation treatment. Patients presented for consultation on their own initiative for residual respiratory symptoms under background treatment with ICS+LABA. The investigating pulmonologist who offered consultations to all scheduled patients, on the occasion of the consultation, also checked the inclusion and exclusion criteria. If the patient did not meet the study entry criteria, they were assessed and received the appropriate treatment, and if the study entry criteria were met, the patient signed the consent and followed the steps recommended by the investigating pulmonologist. As a result, patient entry into the study was randomised 1:1, meaning that the first patient was recommended the inhaler device by the doctor and the next patient entered into the study was left to decide for themselves which type of device was most suitable for them. In both groups, the percentage of patients who had a different choice of inhaler device from that of their doctor was statistically significant.
Compliance to treatment at T12 was found to be low, but compared to results previously published on compliance, in our analysis, compliance was higher and the only reasons identified as responsible for the better results were related to the selection of the target groups and the regular assessments, where, in addition to reviewing the inhaler technique, patients were encouraged to continue treatment, thus creating a strong bond between patient and doctor.
Our analysis revealed that empowering patients by involving them in the inhaler selection process increases adherence to inhaler treatment, reduces the number of mistakes in inhaler use of the inhaler device, and implicitly the number of exacerbations.
吸入器疗法在控制慢性阻塞性肺疾病(COPD)患者的呼吸道症状方面起着关键作用。吸入器装置使用不正确或部分正确会导致许多慢性阻塞性肺疾病(COPD)患者因吸入技术不佳导致药物在气道中沉积不良而持续出现呼吸道症状,进而因病情加重和多次急诊就诊导致医疗费用增加。为每个患者选择合适的吸入器装置对医生和慢性阻塞性肺疾病(COPD)患者来说是一个更大的挑战。吸入器装置的类型和正确的吸入技术取决于慢性阻塞性肺疾病(COPD)症状的控制情况。治疗慢性阻塞性肺疾病(COPD)患者的医生在指导患者正确使用吸入装置方面起着核心作用。医生应在患者家属在场的情况下向患者传授正确使用吸入装置的步骤,以便如果患者在正确操作装置方面有困难,家属能够给予支持。
我们的分析纳入了200名受试者,分为两组——推荐组(RG)和选择组(CG),主要目的是确定慢性阻塞性肺疾病(COPD)患者在决定哪种吸入器装置最适合自己时的行为。在12个月的随访期内对两组进行了三次监测。监测要求患者亲自到研究医生的办公室。该研究纳入了年龄超过40岁、诊断为慢性阻塞性肺疾病(COPD)、根据GOLD指南分期为B和C风险组、正在接受吸入性ICS + LABA治疗的吸烟者、既往吸烟者和/或大量接触职业污染物的患者,尽管他们有接受LAMA + LABA双重支气管扩张治疗的指征。患者在ICS + LABA背景治疗下因残留呼吸道症状主动前来咨询。为所有预约患者提供咨询的研究肺科医生在咨询时也检查了纳入和排除标准。如果患者不符合研究入选标准,他们将接受评估并接受适当治疗,如果符合研究入选标准,患者签署知情同意书并遵循研究肺科医生推荐的步骤。结果,患者进入研究是随机的1:1,即第一个患者由医生推荐吸入器装置,下一个进入研究的患者自行决定哪种装置最适合自己。在两组中,选择与医生推荐不同吸入器装置的患者百分比具有统计学意义。
发现T12时的治疗依从性较低,但与之前发表的关于依从性的结果相比,在我们的分析中,依从性更高,确定导致更好结果的唯一原因与目标人群的选择和定期评估有关,在定期评估中,除了检查吸入技术外,还鼓励患者继续治疗,从而在患者和医生之间建立了牢固的联系。
我们的分析表明,让患者参与吸入器选择过程以增强其自主权可提高吸入器治疗的依从性,减少吸入器装置使用中的错误数量,进而减少病情加重的次数。