Alshamrani Abdullah, Alhotan Abdulaziz, Kelly Elizabeth, Ellakwa Ayman
Oral Rehabilitation & Dental Biomaterial and Bioengineering, The University of Sydney, Sydney 2006, Australia.
Department of Dental Health, College of Applied Medical Sciences, King Saud University, Riyadh P.O. Box 12372, Saudi Arabia.
Polymers (Basel). 2023 May 30;15(11):2523. doi: 10.3390/polym15112523.
This study aimed to assess the mechanical and biocompatibility properties of dental resin reinforced with different nanoparticle additives. Temporary crown specimens were 3D-printed and grouped based on nanoparticle type and amount, including zirconia and glass silica. Flexural strength testing evaluated the material's ability to withstand mechanical stress using a three-point bending test. Biocompatibility was tested using MTT and dead/live cell assays to assess effects on cell viability and tissue integration. Fractured specimens were analysed using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) for fracture surface examination and elemental composition determination. Results show that adding 5% glass fillers and 10-20% zirconia nanoparticles significantly improves the flexural strength and biocompatibility of the resin material. Specifically, the addition of 10%, 20% zirconia, and 5% glass silica by weight significantly increases the flexural strength of the 3D-printed resins. Biocompatibility testing reveals cell viabilities greater than 80% in all tested groups. Reinforced 3D-printed resin holds clinical potential for restorative dentistry, as zirconia and glass fillers have been shown to enhance mechanical and biocompatibility properties of dental resin, making it a promising option for dental restorations. The findings of this study may contribute to the development of more effective and durable dental materials.
本研究旨在评估添加不同纳米颗粒添加剂的牙科树脂的机械性能和生物相容性。临时牙冠标本通过3D打印制作，并根据纳米颗粒类型和数量进行分组，包括氧化锆和玻璃二氧化硅。弯曲强度测试使用三点弯曲试验评估材料承受机械应力的能力。使用MTT和死活细胞检测法测试生物相容性，以评估对细胞活力和组织整合的影响。对断裂的标本使用扫描电子显微镜（SEM）和能量色散X射线光谱仪（EDS）进行分析，以检查断裂表面并确定元素组成。结果表明，添加5%的玻璃填料和10%-20%的氧化锆纳米颗粒可显著提高树脂材料的弯曲强度和生物相容性。具体而言，按重量添加10%、20%的氧化锆和5%的玻璃二氧化硅可显著提高3D打印树脂的弯曲强度。生物相容性测试显示，所有测试组的细胞活力均大于80%。增强的3D打印树脂在修复牙科领域具有临床应用潜力，因为氧化锆和玻璃填料已被证明可增强牙科树脂的机械性能和生物相容性，使其成为牙科修复的一个有前景的选择。本研究结果可能有助于开发更有效、更耐用的牙科材料。
