姜黄素对制霉菌素耐药菌的抗真菌作用研究。
Investigation of the antifungal effects of curcumin against nystatin-resistant .
作者信息
Hajifathali Soha, Lesan Simin, Lotfali Ensieh, Salimi-Sabour Ebrahim, Khatibi Mandana
机构信息
Dentist, Private Practice, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Oral Medicine, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
出版信息
Dent Res J (Isfahan). 2023 Apr 26;20:50. eCollection 2023.
BACKGROUND
Emergence of nystatin-resistant () strains has raised some concerns in the recent years. Recent scientific evidence proves that turmeric, especially curcumin, has anti-inflammatory and anti-fungal activity. The aim of this study was the investigation of the antifungal effects of curcumin against nystatin-resistant .
MATERIALS AND METHODS
This , experimental study evaluated standard-strain (ATCC 16201) and 10 nystatin-resistant strains. The antifungal activity and minimum inhibitory concentration (MIC) of curcumin were evaluated using the CLSI-M27-A3, and the MIC of curcumin was compared with that of nystatin. The results were analyzed using the one-way ANOVA.
RESULTS
The MIC of curcumin was 15.6, 32.25, 15.6, 7.8, 32.25, 15.6, 15.6, 15.6, 32.25, and 15.6 μg/mL for the 10 resistant strains and 62.5 μg/mL for the standard strain of . Curcumin in the above-mentioned concentrations significantly inhibited the proliferation of nystatin-resistant strains ( < 0.001).
CONCLUSION
According to this research, it was shown that curcumin with MIC value of 7.8-32.25 μg/mL has inhibitory effects on nystatin-resistant strains.
背景
近年来，耐制霉菌素的白色念珠菌菌株的出现引起了一些关注。最近的科学证据证明，姜黄，尤其是姜黄素，具有抗炎和抗真菌活性。本研究的目的是调查姜黄素对耐制霉菌素白色念珠菌的抗真菌作用。
材料与方法
本实验研究评估了标准菌株（ATCC 16201）和10株耐制霉菌素的白色念珠菌菌株。使用CLSI-M27-A3评估姜黄素的抗真菌活性和最低抑菌浓度（MIC），并将姜黄素的MIC与制霉菌素的MIC进行比较。结果采用单因素方差分析进行分析。
结果
10株耐药菌株姜黄素的MIC分别为15.6、32.25、15.6、7.8、32.25、15.6、15.6、15.6、32.25和15.6μg/mL，标准菌株的MIC为62.5μg/mL。上述浓度的姜黄素显著抑制了耐制霉菌素白色念珠菌菌株的增殖（P<0.001）。
结论
根据本研究，结果表明MIC值为7.8-32.25μg/mL的姜黄素对耐制霉菌素白色念珠菌菌株具有抑制作用。
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