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姜黄素增强的银功能化石墨烯纳米复合材料对白色念珠菌毒力的光动力影响

Photodynamic impact of curcumin enhanced silver functionalized graphene nanocomposites on Candida virulence.

作者信息

Balakrishnan Dhivyabharathi, Lee Cheng-I

机构信息

Department of Biomedical Sciences, National Chung Cheng University, Min-Hsiung, Chiayi, 62102, Taiwan, ROC.

Center for Nano Bio-Detections, National Chung Cheng University, Min-Hsiung, Chiayi, 62102, Taiwan, ROC.

出版信息

Discov Nano. 2024 Apr 29;19(1):71. doi: 10.1186/s11671-024-04017-5.

DOI:10.1186/s11671-024-04017-5
PMID:38683264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11058173/
Abstract

Candida species are escalating resistance to conventional antifungal treatments, intensifying their virulence, and obstructing the effectiveness of antifungal medications. Addressing this challenge is essential for effectively managing Candida infections. The overarching objective is to advance the development of more efficient and precise therapies tailored to counter Candida infections. This study focuses on developing antifungal combined drugs using curcumin-enhanced silver-functionalized graphene nanocomposites (Cur-AgrGO) to effectively target key virulence factors of C. albicans, C. tropicalis, and C. glabrata (Candida spp.). The green reduction of graphene oxide (GO) using bioentities and active molecules makes this approach cost-effective and environmentally friendly. The nanocomposites were characterized using various techniques. Combining Cur-AgrGO with photodynamic therapy (PDT) demonstrated effective antifungal and antibiofilm activity with delayed growth and metabolism. The nanocomposites effectively suppressed hyphal transition and reduced key virulence factors, including proteinases, phospholipases, ergosterol levels, and cell membrane integrity. The findings suggest that Cur-AgrGO + PDT has potential as a treatment option for Candida infections. This innovative approach holds promise for treating Candida infections.

摘要

念珠菌属对传统抗真菌治疗的耐药性不断增强，其毒力不断加剧，且抗真菌药物的疗效受到阻碍。应对这一挑战对于有效管理念珠菌感染至关重要。总体目标是推动开发更高效、更精准的疗法以对抗念珠菌感染。本研究聚焦于利用姜黄素增强的银功能化石墨烯纳米复合材料（Cur-AgrGO）开发抗真菌联合药物，以有效靶向白色念珠菌、热带念珠菌和光滑念珠菌（念珠菌属）的关键毒力因子。使用生物实体和活性分子对氧化石墨烯（GO）进行绿色还原，使该方法具有成本效益且环保。使用各种技术对纳米复合材料进行了表征。将Cur-AgrGO与光动力疗法（PDT）相结合，显示出有效的抗真菌和抗生物膜活性，生长和代谢延迟。纳米复合材料有效地抑制了菌丝转变，并降低了包括蛋白酶、磷脂酶、麦角固醇水平和细胞膜完整性在内的关键毒力因子。研究结果表明，Cur-AgrGO + PDT有潜力作为念珠菌感染的一种治疗选择。这种创新方法有望用于治疗念珠菌感染。

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