Department of Internal Medicine, ECU Health Medical Center, Brody School of Medicine, Greenville, North Carolina, USA.
Department of Gastroenterology, Mather Hospital, Hofstra University Zucker School of Medicine, Port Jefferson, New York, USA.
Hepatol Commun. 2023 Jun 14;7(7). doi: 10.1097/HC9.0000000000000180. eCollection 2023 Jul 1.
We examined trends in alcohol-associated liver disease (ALD)-related mortality in the United States from 1999 to 2022, focusing on sex, racial differences, and specific age groups. We analyzed age-adjusted mortality rates for ALD-related deaths using the CDC WONDER database and assessed differences between sex and racial groups. ALD-related mortality rates increased significantly between 1999 and 2022, with a more pronounced increase in females. White, Asian, Pacific Islander (AAPI), and American Indian or Alaska Native (AI/AN) groups showed significant uptrends in ALD-related mortality, while African Americans (AA) experienced a nonsignificant decline. Age-specific trends revealed substantial increases in crude mortality rates across various age groups, with the largest increase observed in the younger age groups of 25-34 years, with an average percent change of 11.12% from 2006 to 2022 (average annual percent change of 7.1% for the study period), and 35-44 years, which showed an average percent change of 17.2% from 2018 to 2022 (average annual percent change of 3.8% for the study period). This study reveals increased ALD-related mortality rates in the United States from 1999 to 2022, with disparities among sex, racial groups, and younger age groups. Continued monitoring and evidence-based interventions are needed to address the growing burden of ALD-related mortality, particularly in the younger population.
我们研究了 1999 年至 2022 年期间美国与酒精相关的肝脏疾病（ALD）相关死亡率的趋势，重点关注性别、种族差异和特定年龄组。我们使用疾病预防控制中心 WONDER 数据库分析了年龄调整后的 ALD 相关死亡的死亡率，并评估了性别和种族群体之间的差异。1999 年至 2022 年间，ALD 相关死亡率显著上升，女性的上升幅度更为明显。白人、亚洲人、太平洋岛民（AAPI）和美洲印第安人或阿拉斯加原住民（AI/AN）群体的 ALD 相关死亡率呈显著上升趋势，而非裔美国人（AA）的死亡率则呈下降趋势。特定年龄组的趋势显示，各年龄组的粗死亡率均有大幅上升，其中 25-34 岁年龄组的增长率最大，2006 年至 2022 年期间平均百分比变化为 11.12%（研究期间的平均年百分比变化为 7.1%），35-44 岁年龄组的增长率最大，2018 年至 2022 年期间平均百分比变化为 17.2%（研究期间的平均年百分比变化为 3.8%）。本研究显示，1999 年至 2022 年期间美国的 ALD 相关死亡率上升，性别、种族群体和年轻年龄组之间存在差异。需要继续监测和采取基于证据的干预措施，以应对 ALD 相关死亡率不断上升的问题，特别是在年轻人群中。
