Eliasson I
Drugs. 1986;31 Suppl 3:7-10. doi: 10.2165/00003495-198600313-00004.
A protein antigen--P-antigen--characteristic of Branhamella catarrhalis has been described. Precipitating antibodies against this antigen occur in a majority of healthy human sera; serological evidence for a pathogenic role of B. catarrhalis is accumulating. The occurrence of complement-fixing antibodies has been demonstrated during bronchopulmonary infection with B. catarrhalis and in maxillary sinusitis. Increases in antibody titres assessed by an enzyme-linked immunosorbent assay (ELISA) technique have been reported in children with acute otitis media. An ELISA, using purified P-antigen, for the evaluation of IgG, IgM and IgA antibodies against B. catarrhalis is being developed.
已描述了一种卡他莫拉菌特有的蛋白质抗原——P抗原。针对该抗原的沉淀抗体存在于大多数健康人血清中；关于卡他莫拉菌致病作用的血清学证据正在积累。在卡他莫拉菌引起的支气管肺部感染以及上颌窦炎期间，已证实存在补体结合抗体。据报道，采用酶联免疫吸附测定（ELISA）技术评估，急性中耳炎患儿的抗体滴度会升高。一种使用纯化P抗原的ELISA正在研发中，用于评估针对卡他莫拉菌的IgG、IgM和IgA抗体。
