嗅鞘细胞在胶原水凝胶中用于实验性脊髓囊肿治疗的应用
Application of Olfactory Ensheathing Cells in Collagen Hydrogels for Therapy of Experimental Spinal Cord Cysts.
作者信息
Fursa G A, Mukhina A I, Chadin A V, Karsuntseva E K, Voronova A D, Shishkina V S, Lazareva P A, Stepanenko A A, Reshetov I V, Stepanova O V, Chekhonin V P
机构信息
V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2025 Feb;178(4):560-566. doi: 10.1007/s10517-025-06373-3. Epub 2025 Mar 28.
Therapeutic efficacy of olfactory ensheathing cells and type I collagen administered separately or in combination was studied in a model of chronic spinal cord injury in rats. The introduction of collagen hydrogel at a concentration of 4 mg/ml with and without olfactory ensheathing cells into spinal cord cysts reduced cyst volume and restored hindlimb motor function. The introduction of collagen hydrogel at both concentrations (1 and 4 mg/ml) with and without ensheathing cells stimulated remyelination of damaged nerve tissue. The results show that further study of this bioengineered preparation, as well as other combinations with cells or hydrogels is promising for the treatment of spinal cord injuries.
在大鼠慢性脊髓损伤模型中，研究了单独或联合给予嗅鞘细胞和I型胶原蛋白的治疗效果。将浓度为4mg/ml的胶原蛋白水凝胶单独或与嗅鞘细胞一起引入脊髓囊肿，可减少囊肿体积并恢复后肢运动功能。将两种浓度（1mg/ml和4mg/ml）的胶原蛋白水凝胶单独或与嗅鞘细胞一起引入，均能刺激受损神经组织的髓鞘再生。结果表明，对这种生物工程制剂以及与细胞或水凝胶的其他组合进行进一步研究，有望用于治疗脊髓损伤。
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