Williams Frank B, Kader Md Abdul, Dickson Dorothy M, Colgate E Ross, Alam Masud, Haque Rashidul, Petri William A, Kirkpatrick Beth D, Lee Benjamin
Vaccine Testing Center and Translational Global Infectious Diseases Research Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Open Forum Infect Dis. 2023 Jun 7;10(6):ofad299. doi: 10.1093/ofid/ofad299. eCollection 2023 Jun.
Breast milk secretor status is associated with antibody seroconversion to oral rotavirus vaccination. Here, we were unable to detect a similar impact on risk of infant rotavirus diarrhea or vaccine efficacy through 2 years of life, underscoring limitations of immunogenicity assessment alone in evaluation of oral rotavirus vaccine response.
母乳分泌状态与口服轮状病毒疫苗后的抗体血清转化有关。在此,我们未能检测到对2岁以内婴儿轮状病毒腹泻风险或疫苗效力有类似影响,这突出了仅通过免疫原性评估来评价口服轮状病毒疫苗反应的局限性。