母婴分泌型状态影响孟加拉国母乳喂养婴儿口服轮状病毒疫苗的反应。
Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh.
机构信息
The University of Vermont Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
出版信息
J Infect Dis. 2021 Oct 13;224(7):1147-1151. doi: 10.1093/infdis/jiaa101.
Abstract
Secretor status controls mucosal histo-blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with nonsecretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated RV vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] RV vaccine (Rotarix) trial in Bangladesh, RV-specific plasma immunoglobulin A antibody seroconversion rates were higher among infants of maternal nonsecretors (39%) than infants of maternal secretors (23%; P = .001). Maternal status remained a significant predictor when correcting for infant status (P = .002). Maternal secretor status should be considered when interpreting oral RV vaccine responses in low- and middle-income settings. Clinical Trials Registration. NCT01375647.
摘要
分泌状态控制黏膜组织血型抗原的表达，并与轮状病毒（RV）腹泻的易感性相关，非分泌者症状感染的易感性较低。母乳分泌状态对母乳喂养婴儿口服减毒 RV 疫苗反应的影响尚未得到探索。在孟加拉国进行的单价 G1P[8]RV 疫苗（Rotarix）试验中，母亲为非分泌者的婴儿（39%）RV 特异性血浆免疫球蛋白 A 抗体血清转化率高于母亲为分泌者的婴儿（23%；P =.001）。当校正婴儿状态时，母亲状态仍然是一个显著的预测因素（P =.002）。在解释低收入和中等收入国家口服 RV 疫苗反应时，应考虑母体分泌状态。临床试验注册。NCT01375647。
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