Laboratory of Microbiology, Faculty of Medicine, Democritus University of Thrace, Dragana Campus, Alexandroupolis, Greece.
Department of Biopathology/Microbiology, Faculty of Medicine, University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
Front Cell Infect Microbiol. 2023 Jun 2;13:1191126. doi: 10.3389/fcimb.2023.1191126. eCollection 2023.
Intestinal microorganisms play a crucial role in shaping the host immunity and maintaining homeostasis. Nevertheless, alterations in gut bacterial composition may occur and these alterations have been linked with the pathogenesis of several diseases. In surgical practice, studies revealed that the microbiome of patients undergoing surgery changes and several post-operative complications seem to be associated with the gut microbiota composition. In this review, we aim to provide an overview of gut microbiota (GM) in surgical disease. We refer to several studies which describe alterations of GM in patients undergoing different types of surgery, we focus on the impacts of peri-operative interventions on GM and the role of GM in development of post-operative complications, such as anastomotic leak. The review aims to enhance comprehension regarding the correlation between GM and surgical procedures based in the current knowledge. However, preoperative and postoperative synthesis of GM needs to be further examined in future studies, so that GM-targeted measures could be assessed and the different surgery complications could be reduced.
肠道微生物在塑造宿主免疫和维持体内平衡方面起着至关重要的作用。然而，肠道细菌组成的改变可能会发生，这些改变与多种疾病的发病机制有关。在外科实践中，研究表明接受手术的患者的微生物组发生了变化，并且几种术后并发症似乎与肠道微生物群落组成有关。在这篇综述中，我们旨在概述外科疾病中的肠道微生物组。我们参考了几篇描述不同类型手术患者肠道微生物组改变的研究，我们重点关注围手术期干预对肠道微生物组的影响，以及肠道微生物组在术后并发症发展中的作用，如吻合口漏。该综述旨在基于现有知识增强对肠道微生物组与外科手术之间相关性的理解。然而，需要进一步在未来的研究中检查术前和术后肠道微生物组的合成，以便评估针对肠道微生物组的措施，并减少不同的手术并发症。
