Department of Chemistry, Maulana Azad National Institute of Technology, Bhopal 462003, India.
Department of Mechanical Engineering, Maulana Azad National Institute of Technology, Bhopal 462003, India.
Biosci Rep. 2023 Jul 26;43(7). doi: 10.1042/BSR20230151.
It has become crucial to biosynthesize efficient, secure, and affordable nanoparticles that we use for the treatment of various infections, including surgical site infection and wound infection, due to the rapid development of microbial resistance to numerous antibiotic drugs. The objective of the present study is to biosynthesize cobalt nanoparticles using an extract from the combined peels of garlic (Allium sativum) and onion (Allium cepa). Scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction were used to confirm the synthesis of cobalt nanoparticle (XRD). Well diffusion was used to measure antimicrobial activity. Escherichia coli, Proteus, Staphylococcus aureus, Staphylococcus cohnii, and Klebsiella pneumonia were the bacterial strains employed Both the crude prepared extract and the biosynthesized cobalt nanoparticles demonstrated efficacy against all strains of bacteria, but the crude prepared extract displayed a low zone of inhibition ranging from 10 to 13 mm, while the biosynthesized cobalt nanoparticles displayed a high zone of inhibition ranging from 20 to 24 mm.
由于微生物对许多抗生素药物的耐药性迅速发展，因此合成高效、安全且经济实惠的纳米粒子用于治疗各种感染（包括手术部位感染和伤口感染）变得至关重要。本研究的目的是使用大蒜（Allium sativum）和洋葱（Allium cepa）的组合果皮提取物来合成钴纳米粒子。扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）和 X 射线衍射（XRD）用于确认钴纳米粒子的合成。采用琼脂扩散法测定抗菌活性。大肠杆菌、变形杆菌、金黄色葡萄球菌、凝固酶阴性葡萄球菌和肺炎克雷伯菌是所用的细菌菌株。粗提物和生物合成的钴纳米粒子都对所有细菌菌株有效，但粗提物的抑菌圈直径范围为 10 至 13 毫米，而生物合成的钴纳米粒子的抑菌圈直径范围为 20 至 24 毫米。
