Zrein M, Burckard J, Van Regenmortel M H
J Virol Methods. 1986 May;13(2):121-8. doi: 10.1016/0166-0934(86)90079-0.
The biotin-avidin detection system was used in direct and indirect ELISA for detecting a broad range of serologically related tobamoviruses. When compared to standard ELISA procedures that use antibodies labelled with alkaline phosphatase, the biotin-avidin system increased the assay sensitivity and allowed a wider range of related viral serotypes to be detected.