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提高互联网强迫症自助治疗的依从性:一项随机对照试验。

Improving adherence to unguided Internet-based therapy for obsessive-compulsive disorder: A randomized controlled trial.

机构信息

Department of Psychotherapy and Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Department of Psychotherapy and Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute for Clinical Psychology and Psychotherapy, Department of Psychology, Medical School Hamburg, Hamburg, Germany.

出版信息

J Affect Disord. 2023 Oct 1;338:472-481. doi: 10.1016/j.jad.2023.06.038. Epub 2023 Jun 20.

Abstract

BACKGROUND

Adherence to internet-based cognitive-behavioral therapy (iCBT) is often low, possibly reducing its potential. The current study set out to test whether adherence and effects of unguided iCBT for obsessive-compulsive disorder (OCD) could be improved by varying the degree of autonomy in which modules are completed (free choice vs. fixed order).

METHODS

We randomized 151 individuals with OCD to either an unguided iCBT with a fixed (iCBTfixed) or a free-choice (iCBTfree+) order of the modules. We assessed participants at baseline (t0), eight weeks (t1), and 16 weeks (t2). Primary outcomes were adherence (utilization time, modules completed) and change in OCD severity (Y-BOCS). Secondary outcomes included depression, self-esteem, and treatment satisfaction. We calculated intent-to-treat (ITT) and complete case (CC) analyses.

RESULTS

Analyses showed that both iCBT programs significantly reduced OCD severity. While groups did not differ on the ITT analyses, for the CC analyses, a greater improvement was found in the iCBTfixed in comparison to the iCBTfree+ group regarding OCD severity and quality of life, with medium effect sizes from t0 to t1 (η = 0.067-0.077). Time of utilization and number of modules completed did not differ between groups.

LIMITATIONS

No placebo control group, short follow-up period, self-report assessment.

CONCLUSIONS

iCBT is effective in improving OCD. Despite similar adherence in the fixed versus the free-choice module order, the study offers tentative evidence that a fixed order of content is associated with better effects. More research on the effects of adherence on outcome is necessary.

摘要

背景

基于互联网的认知行为疗法(iCBT)的依从性通常较低,这可能降低了其潜在效果。本研究旨在测试通过改变模块完成的自主性程度(自由选择与固定顺序),是否可以提高强迫症(OCD)的未指导 iCBT 的依从性和效果。

方法

我们将 151 名强迫症患者随机分配到固定顺序(iCBTfixed)或自由选择顺序(iCBTfree+)的未指导 iCBT 组。我们在基线(t0)、八周(t1)和十六周(t2)评估参与者。主要结局是依从性(利用时间、完成的模块)和 OCD 严重程度的变化(Y-BOCS)。次要结局包括抑郁、自尊和治疗满意度。我们计算了意向治疗(ITT)和完全案例(CC)分析。

结果

分析表明,两种 iCBT 方案均显著降低了 OCD 严重程度。虽然 ITT 分析中两组没有差异,但在 CC 分析中,与 iCBTfree+组相比,iCBTfixed 组在 OCD 严重程度和生活质量方面的改善更大,从 t0 到 t1 的效应量为中等(η=0.067-0.077)。利用时间和完成的模块数量在两组之间没有差异。

局限性

没有安慰剂对照组,随访时间短,自我报告评估。

结论

iCBT 有效改善 OCD。尽管固定顺序与自由选择模块顺序的依从性相似,但该研究提供了初步证据,表明固定的内容顺序与更好的效果相关。需要更多关于依从性对结果影响的研究。

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