Lahav Yair, Kfir Aviv, Gepner Yftach
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, and Sylvan Adams Sports Institute, Tel-Aviv, Israel.
Front Nutr. 2023 Jun 9;10:1173488. doi: 10.3389/fnut.2023.1173488. eCollection 2023.
To evaluate the prevalence of excessive adiposity among normal-weight individuals, and their cardiometabolic risk.
This cross-sectional study included 3,001 participants (ages 20-95, 52% men, BMI 28.0 ± 5.5 kg/m) who completed an anthropometric evaluation, dual x-ray absorptiometry (DXA) scan to measure body composition, and cardiometabolic blood markers. Excess adiposity was defined as ≥25% for men and ≥ 35% for women.
Of the entire study participants, 967 were in normal BMI (18.5-24.9 kg/m) with a wide body fat distribution (4-49%). Of them, 26% of men and 38% of women were classified with excess adiposity. As compared to normal-weight lean participants, normal-weight obese men and women had higher triglycerides (76.5 ± 37.3 vs. 101.2 ± 50.3 mg/dL, = 0.004 and 84 ± 44.2 vs. 101.4 ± 91.1 mg/dL, = 0.030; respectively) and elevated low-density lipoprotein cholesterol (103.3 ± 31.7 vs. 119.6 ± 45.5 mg/dL, = 0.011) and total cholesterol (171.5 ± 40.3 vs. 190.2 ± 39 mg/dL, = 0.007) for men only. Among NWO, abdominal circumference was prevalent in 60% of the females with NWO (≥88 cm), but only in 4% of males (≥102 cm).
Higher adiposity, even within normal weight, increases cardiometabolic risk, and abdominal waist circumference misclassified obesity in normal-weight individuals. This study highlights the need for a body composition evaluation to determine cardiometabolic risk for adults with normal body weight.
评估正常体重个体中肥胖过度的患病率及其心脏代谢风险。
这项横断面研究纳入了3001名参与者（年龄20 - 95岁，男性占52%，体重指数[BMI]为28.0±5.5kg/m²），他们完成了人体测量评估、双能X线吸收法（DXA）扫描以测量身体成分，以及心脏代谢血液标志物检测。肥胖过度定义为男性≥25%，女性≥35%。
在整个研究参与者中，967人BMI正常（18.5 - 24.9kg/m²），但体脂分布范围较广（4% - 49%）。其中，26%的男性和38%的女性被归类为肥胖过度。与正常体重且体型偏瘦的参与者相比，正常体重且肥胖的男性和女性甘油三酯水平更高（男性：76.5±37.3对101.2±50.3mg/dL，P = 0.004；女性：84±44.2对101.4±91.1mg/dL，P = 0.030），且仅男性的低密度脂蛋白胆固醇升高（103.3±31.7对119.6±45.5mg/dL，P = 0.011）以及总胆固醇升高（171.5±40.3对190.2±39mg/dL，P = 0.007）。在正常体重且肥胖的人群中，60%的女性腰围超标（≥88cm），但只有4%的男性腰围超标（≥102cm）。
即使在正常体重范围内，较高的肥胖程度也会增加心脏代谢风险，并且腰围会导致正常体重个体的肥胖分类错误。本研究强调需要进行身体成分评估，以确定正常体重成年人的心脏代谢风险。
