Medical College, Tianjin University, Tianjin 300072, China.
Biosensors (Basel). 2023 May 31;13(6):598. doi: 10.3390/bios13060598.
The biomedical field has always fostered innovation and the development of various new technologies. Beginning in the last century, demand for picoampere-level current detection in biomedicine has increased, leading to continuous breakthroughs in biosensor technology. Among emerging biomedical sensing technologies, nanopore sensing has shown great potential. This paper reviews nanopore sensing applications, such as chiral molecules, DNA sequencing, and protein sequencing. However, the ionic current for different molecules differs significantly, and the detection bandwidths vary as well. Therefore, this article focuses on current sensing circuits, and introduces the latest design schemes and circuit structures of different feedback components of transimpedance amplifiers mainly used in nanopore DNA sequencing.
生物医学领域一直以来都孕育着创新和各种新技术的发展。从上世纪开始，生物医学领域对皮安级电流检测的需求不断增加，这推动了生物传感器技术的持续突破。在新兴的生物医学传感技术中，纳米孔传感技术展现出了巨大的潜力。本文综述了纳米孔传感技术在检测手性分子、DNA 测序和蛋白质测序等方面的应用。然而，不同分子的离子电流差异显著，检测带宽也不同。因此，本文主要关注电流传感电路，并介绍了纳米孔 DNA 测序中主要使用的跨阻放大器不同反馈元件的最新设计方案和电路结构。
