School of Science, China University of Geosciences (Beijing), Beijing 100083, China.
Biosensors (Basel). 2023 Jun 8;13(6):636. doi: 10.3390/bios13060636.
The rapid development of advanced material science boosts novel chemical analytical technologies for effective pretreatment and sensitive sensing applications in the fields of environmental monitoring, food security, biomedicines, and human health. Ionic covalent organic frameworks (iCOFs) emerge as a class of covalent organic frameworks (COFs) with electrically charged frames or pores as well as predesigned molecular and topological structures, large specific surface area, high crystallinity, and good stability. Benefiting from the pore size interception effect, electrostatic interaction, ion exchange, and recognizing group load, iCOFs exhibit the promising ability to extract specific analytes and enrich trace substances from samples for accurate analysis. On the other hand, the stimuli response of iCOFs and their composites to electrochemical, electric, or photo-irradiating sources endows them as potential transducers for biosensing, environmental analysis, surroundings monitoring, etc. In this review, we summarized the typical construction of iCOFs and focused on their rational structure design for analytical extraction/enrichment and sensing applications in recent years. The important role of iCOFs in the chemical analysis was fully highlighted. Finally, the opportunities and challenges of iCOF-based analytical technologies were also discussed, which may be beneficial to provide a solid foundation for further design and application of iCOFs.
先进材料科学的快速发展推动了新型化学分析技术的发展，这些技术在环境监测、食品安全、生物医学和人类健康等领域具有有效的预处理和敏感传感应用。离子共价有机骨架 (iCOFs) 作为一类带有电荷的骨架或孔以及预定的分子和拓扑结构的共价有机骨架 (COFs) 出现，具有大的比表面积、高结晶度和良好的稳定性。受益于孔径截留效应、静电相互作用、离子交换和识别基团负载，iCOFs 表现出从样品中提取特定分析物和浓缩痕量物质以进行准确分析的有前途的能力。另一方面，iCOFs 及其复合材料对电化学、电或光辐照源的刺激响应使它们成为生物传感、环境分析、环境监测等领域的潜在传感器。在这篇综述中，我们总结了 iCOFs 的典型结构，并重点介绍了近年来它们在分析提取/富集和传感应用中的合理结构设计。充分强调了 iCOFs 在化学分析中的重要作用。最后，还讨论了基于 iCOFs 的分析技术的机遇和挑战，这可能有助于为 iCOFs 的进一步设计和应用提供坚实的基础。
