Baba Dragos-Florin, Suciu Horatiu, Huma Laurentiu, Avram Calin, Danilesco Alina, Moldovan Diana Andreea, Opincar Andrei Stefan, Sin Anca Ileana
Emergency Institute for Cardiovascular Diseases and Transplantation, 540142 Targu Mures, Romania.
Department of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mures, 540142 Targu Mures, Romania.
J Cardiovasc Dev Dis. 2023 May 31;10(6):241. doi: 10.3390/jcdd10060241.
The platelet-to-albumin ratio (PAR), leucocyte-to-albumin ratio (LAR), neutrophil percentage-to-albumin ratio (NPAR), and monocyte-to-albumin ratio (MAR) represent easily reproducible markers, which may predict the outcomes in various diseases. Early postoperative complications might appear after heart transplantation, such as infections, diabetes mellitus type 2 (DM2), acute graft rejection, and atrial fibrillation (AFib).
The aim of our study was to investigate the PAR, LAR, NPAR, and MAR values before and after heart transplantation, and the associations of the preoperative levels of these markers with the presence of postoperative complications in first two months after surgery.
Our retrospective research was directed from May 2014 to January 2021, with a total number of 38 patients being included. We used cut-off values for the ratios from previously published studies, as well as our own determination of these levels by using a receiver operating characteristic (ROC) curve.
By ROC analysis, the optimal preoperative PAR cut-off value was 38.84 (AUC: 0.771, = 0.0039), with 83.3% sensitivity, and 75.0% specificity. Applying a Chi square (χ) test, PAR > 38.84 represented an independent risk factor for complications, regardless of cause, and postoperative infections.
Preoperative PAR > 38.84 was a risk factor of developing complications of any cause, and postoperative infections in the first two months after heart transplantation.
血小板与白蛋白比值（PAR）、白细胞与白蛋白比值（LAR）、中性粒细胞百分比与白蛋白比值（NPAR）以及单核细胞与白蛋白比值（MAR）是易于重复测量的指标，可能预测多种疾病的预后。心脏移植术后早期可能出现并发症，如感染、2型糖尿病（DM2）、急性移植物排斥反应和心房颤动（AFib）。
本研究旨在调查心脏移植前后的PAR、LAR、NPAR和MAR值，以及这些指标术前水平与术后前两个月并发症发生情况之间的关联。
我们的回顾性研究时间为2014年5月至2021年1月，共纳入38例患者。我们采用了先前发表研究中的比值临界值，以及我们自己通过绘制受试者工作特征（ROC）曲线来确定这些水平。
通过ROC分析，术前PAR的最佳临界值为38.84（曲线下面积：0.771，P = 0.0039），敏感性为83.3%，特异性为75.0%。应用卡方（χ²）检验，PAR > 38.84是并发症的独立危险因素，无论病因如何，包括术后感染。
术前PAR > 38.84是心脏移植术后前两个月发生任何原因并发症及术后感染的危险因素。
