Atanasova Tsvetelina, Stankova Teodora, Bivolarska Anelia, Vlaykova Tatyana
Faculty of Dental Medicine, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Department of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Biomedicines. 2023 May 23;11(6):1514. doi: 10.3390/biomedicines11061514.
Matrix metalloproteinases (MMPs) are a large family of Ca and Zn dependent proteolytic enzymes, able to cleave the various components of the extracellular matrix (ECM), as well as a range of other regulatory molecules. Several reports have proven the important role of both MMPs and their endogenous inhibitors, TIPMs, in oral health, the initial development of the tooth, and during enamel maturation. In this mini-review, we aim to summarize the literature information about the functions of MMPs, paying more attention to MMP-8 (collagenase-2 or neutrophil collagenase) in the development and progression of periodontitis, peri-implantitis, and carious lesions. We also emphasize the role of particular gene variants in as predisposing factors for some oral diseases.
基质金属蛋白酶（MMPs）是一大类依赖钙和锌的蛋白水解酶，能够裂解细胞外基质（ECM）的各种成分以及一系列其他调节分子。多项报告已证实MMPs及其内源性抑制剂TIPMs在口腔健康、牙齿的初始发育以及釉质成熟过程中的重要作用。在本综述中，我们旨在总结有关MMPs功能的文献信息，尤其关注MMP-8（胶原酶-2或中性粒细胞胶原酶）在牙周炎、种植体周围炎和龋病病变的发生发展中的作用。我们还强调特定基因变异作为某些口腔疾病的易感因素的作用。
