Matsas Alkis, Sachinidis Athanasios, Lamprinou Malamatenia, Stamoula Eleni, Christopoulos Panagiotis
Second Department of Obstetrics and Gynaecology, Medical School, "Aretaieion'' University Hospital, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
Fourth Department of Internal Medicine, Hippokration General Hospital of Thessaloniki, School of Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Life (Basel). 2023 Jun 1;13(6):1308. doi: 10.3390/life13061308.
Primary dysmenorrhea is considered to be one of the most common gynecological complaints, affecting women's daily activities and social life. The severity of dysmenorrhea varies among women, and its management is of high importance for them. Given that non-steroidal anti-inflammatory drugs (NSAIDs), the established treatment for dysmenorrhea, are associated with many adverse events, alternative therapeutic options are under evaluation. Emerging evidence correlates management of dysmenorrhea with micronutrients, especially vitamins.
The aim of this narrative review is to highlight and provide evidence of the potential benefits of vitamins for the management of dysmenorrhea.
The articles were searched on PubMed, Scopus and Google Scholar. The searching process was based on keywords, such as "primary dysmenorrhea", "vitamins", "supplementation", "vitamin D", "vitamin E" and others. Our search focused on data derived from clinical trials, published only during the last decade (older articles were excluded).
In this review, 13 clinical trials were investigated. Most of them supported the anti-inflammatory, antioxidant and analgesic properties of vitamins. Particularly, vitamins D and E revealed a desirable effect on dysmenorrhea relief Conclusion: Despite the scarcity and heterogeneity of related research, the studies indicate a role of vitamins for the management of primary dysmenorrhea, proposing that they should be considered as alternative therapeutic candidates for clinical use. Nevertheless, this correlation warrants further research.
原发性痛经被认为是最常见的妇科病症之一，影响着女性的日常活动和社交生活。痛经的严重程度因人而异，对其进行管理对女性而言至关重要。鉴于痛经的既定治疗药物非甾体抗炎药（NSAIDs）会引发诸多不良事件，其他治疗选择正在评估之中。新出现的证据表明痛经的管理与微量营养素，尤其是维生素有关。
本叙述性综述的目的是强调并提供维生素在痛经管理方面潜在益处的证据。
在PubMed、Scopus和谷歌学术上检索文章。检索过程基于关键词，如“原发性痛经”“维生素”“补充剂”“维生素D”“维生素E”等。我们的检索集中于仅在过去十年发表的临床试验数据（排除旧文章）。
本综述对13项临床试验进行了研究。其中大多数支持维生素的抗炎、抗氧化和镇痛特性。特别是，维生素D和E对缓解痛经显示出理想效果。结论：尽管相关研究稀缺且存在异质性，但这些研究表明维生素在原发性痛经管理中发挥作用，建议将其视为临床使用的替代治疗候选药物。然而，这种相关性有待进一步研究。
