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THC 降低型大麻素-L-溶剂如何决定口服时大麻素的生物利用度？

THC-Reduced L.-How Does the Solvent Determine the Bioavailability of Cannabinoids Given Orally?

机构信息

Physiology Department, Poznan University of Medical Sciences, ul. Święcickiego 6, 61-861 Poznań, Poland.

Cannabitey s.c. Poznań, ul. Uniwersytetu Poznańskiego 10/B123, 61-614 Poznań, Poland.

出版信息

Nutrients. 2023 Jun 6;15(12):2646. doi: 10.3390/nu15122646.

DOI:10.3390/nu15122646
PMID:37375550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10304291/
Abstract

The bioavailability levels of cannabidiol (CBD) and tetrahydrocannabinol (THC) determine their pharmacological effects. Therefore, for medical purposes, it is essential to obtain extracts containing the lowest possible content of the psychogenic component THC. In our extract, the CBD/THC ratio was 16:1, which is a high level compared to available medical preparations, where it is, on average, 1:1. This study assessed the bioavailability and stability of CBD and THC derived from L. with reduced THC content. The extract was orally administered (30 mg/kg) in two solvents, Rapae oleum and Cremophor, to forty-eight Wistar rats. The whole-blood and brain concentrations of CBD and THC were measured using liquid chromatography coupled with mass spectrometry detection. Much higher concentrations of CBD than THC were observed for both solvents in the whole-blood and brain after oral administration of the extract with a decreased THC content. The total bioavailability of both CBD and THC was higher for Rapae oleum compared to Cremophor. Some of the CBD was converted into THC in the body, which should be considered when using for medical purposes. The THC-reduced hemp extract in this study is a promising candidate for medical applications.

摘要

大麻二酚 (CBD) 和四氢大麻酚 (THC) 的生物利用度水平决定了它们的药理作用。因此，出于医疗目的，获得含有最低可能含量的致幻成分 THC 的提取物至关重要。在我们的提取物中，CBD/THC 比为 16:1，与现有的医疗制剂相比，这是一个很高的水平，平均为 1:1。本研究评估了来源于 L. with reduced THC content 的 CBD 和 THC 的生物利用度和稳定性。以两种溶剂菜籽油和吐温 80 对四十八只 Wistar 大鼠进行口服（30mg/kg）给药。采用液质联用技术测定全血和脑组织中 CBD 和 THC 的浓度。在口服含有降低 THC 含量的提取物后，两种溶剂在全血和脑组织中观察到 CBD 的浓度明显高于 THC。与吐温 80 相比，菜籽油对 CBD 和 THC 的总生物利用度更高。一些 CBD 在体内转化为 THC，在将其用于医疗目的时应予以考虑。本研究中的 THC 降低的大麻素提取物是一种有前途的医疗应用候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/198618c03c4f/nutrients-15-02646-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/0fea7c4b2ad9/nutrients-15-02646-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/d1879fe45af4/nutrients-15-02646-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/cefd77f6536b/nutrients-15-02646-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/198618c03c4f/nutrients-15-02646-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/0fea7c4b2ad9/nutrients-15-02646-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/d1879fe45af4/nutrients-15-02646-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/cefd77f6536b/nutrients-15-02646-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7889/10304291/198618c03c4f/nutrients-15-02646-g004.jpg

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