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脂源对医用大麻油制剂质量特性的影响。

Impact of Lipid Sources on Quality Traits of Medical Cannabis-Based Oil Preparations.

机构信息

Farmacia Dott.ri Giuliana e Alberto Ramella-SAS, Via A. Diaz 1, 21021 Angera (VA), Italy.

Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via L. Mangiagalli 25, 20133 Milan, Italy.

出版信息

Molecules. 2020 Jun 30;25(13):2986. doi: 10.3390/molecules25132986.

DOI:10.3390/molecules25132986
PMID:32629796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7412533/
Abstract

The feasibility of the use of two lipid sources and their impact on the cannabinoid profile, terpene fingerprint, and degradation products in medical cannabis oil preparations during 3 months of refrigerated storage time were investigated. LCHRMS-Orbitrap and HS-SPME coupled to GC-MS for the investigation of targeted and untargeted cannabinoids, terpenes, and lipid degradation products in Bedrocan and Bediol macerated oils were used as analytical approaches. As regards the cannabinoid trend during 90 days of storage, there were no differences between PhEur-grade olive oil (OOPH) and medium-chain triglycerides oil (MCT oil) coupled to a good stability of preparations for the first 60 days both in Bedrocan and Bediol oils. MCT lipid source extracted a significant concentration of terpenes compared to olive oil. Terpenes showed a different scenario since MCT oil displayed the strongest extraction capacity and conservation trend of all compounds during the shelf life. Terpenes remained stable throughout the entire storage period in MCT formulations while a significant decrease after 15 and 30 days in Bediol and Bedrocan was observed in olive oil. Therefore, MCT oil could be considered a more suitable lipid source compared to olive oil involved in the extraction of medical cannabis for magistral preparations.

摘要

研究了在冷藏 3 个月的时间内，使用两种脂源及其对药用大麻油制剂中大麻素谱、萜烯指纹图谱和降解产物的影响。LCHRMS-Orbitrap 和 HS-SPME 与 GC-MS 联用，用于检测 Bedrocan 和 Bediol 浸膏油中的靶向和非靶向大麻素、萜烯和脂类降解产物，作为分析方法。就储存 90 天期间大麻素的趋势而言，在 Bedrocan 和 Bediol 油中，与中链甘油三酯油（MCT 油）相比，PhEur 级橄榄油（OOPH）耦合没有差异，在前 60 天内制剂具有良好的稳定性。与橄榄油相比，MCT 脂源提取了大量的萜烯。萜烯呈现出不同的情况，因为在整个保质期内，MCT 油显示出最强的提取能力和所有化合物的保存趋势。在 MCT 制剂中，萜烯在整个储存期内保持稳定，而在橄榄油中，Bediol 和 Bedrocan 在 15 天和 30 天后观察到显著下降。因此，与橄榄油相比，MCT 油可能是一种更适合用于提取药用大麻的脂源，用于制作处方制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/fb8734f6b288/molecules-25-02986-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/7276608dccc9/molecules-25-02986-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/51ce97d4e901/molecules-25-02986-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/60711438f607/molecules-25-02986-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/e504d67d9b3f/molecules-25-02986-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/229cb8b56722/molecules-25-02986-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/07e768feda84/molecules-25-02986-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/fb8734f6b288/molecules-25-02986-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/7276608dccc9/molecules-25-02986-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/a93e5f1d332d/molecules-25-02986-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/023a/7412533/51ce97d4e901/molecules-25-02986-g003.jpg
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