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PINK1：从帕金森病到线粒体自噬，再回到帕金森病。

PINK1: From Parkinson's disease to mitophagy and back again.

机构信息

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, United Kingdom.

Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, United States of America.

出版信息

PLoS Biol. 2023 Jun 29;21(6):e3002196. doi: 10.1371/journal.pbio.3002196. eCollection 2023 Jun.

DOI:10.1371/journal.pbio.3002196
PMID:37384773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10337960/
Abstract

The genetics of Parkinson's disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade.

摘要

帕金森病的遗传学研究对于揭示 PINK1 依赖性线粒体自噬过程至关重要。在这里，我们将讨论 2010 年发表在《PLOS Biology》上的一篇论文的意义，该论文阐明了 PINK1 在线粒体自噬级联反应中的功能重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/10337960/e54f532119c9/pbio.3002196.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/10337960/e54f532119c9/pbio.3002196.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72e0/10337960/e54f532119c9/pbio.3002196.g001.jpg

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Targeting mitophagy in Parkinson's disease.靶向治疗帕金森病中的线粒体自噬。
J Biol Chem. 2021 Jan-Jun;296:100209. doi: 10.1074/jbc.REV120.014294. Epub 2020 Dec 24.
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Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism.
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