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用甲氟喹或乙胺嘧啶-磺胺多辛单剂量治疗恶性疟。

Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine.

作者信息

Doberstyn E B, Phintuyothin P, Noeypatimanondh S, Teerakiartkamjorn C

出版信息

Bull World Health Organ. 1979;57(2):275-9.

PMID:373903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2395771/
Abstract

A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.

摘要

单次口服1.5克盐酸甲氟喹治愈了37例恶性疟患者，单次口服75毫克乙胺嘧啶加1.5克磺胺多辛治愈了38例患者中的34例。两种治疗方案的疟原虫血症和发热消退率相似，但甲氟喹的胃肠道副作用发生率较高。

相似文献

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Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine.用甲氟喹或乙胺嘧啶-磺胺多辛单剂量治疗恶性疟。
Bull World Health Organ. 1979;57(2):275-9.
2
A double-blind clinical trial of a combination of mefloquine, sulfadoxine and pyrimethamine in symptomatic falciparum malaria.甲氟喹、周效磺胺和乙胺嘧啶联合用药治疗有症状恶性疟的双盲临床试验。
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Prospective double-blind trial of two different doses of mefloquine plus pyrimethamine-sulfadoxine compared with pyrimethamine-sulfadoxine alone in the treatment of falciparum malaria.两种不同剂量的甲氟喹加乙胺嘧啶-磺胺多辛与单用乙胺嘧啶-磺胺多辛治疗恶性疟的前瞻性双盲试验。
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A double-blind trial of a fixed combination of mefloquine plus sulfadoxine-pyrimethamine compared with sulfadoxine-pyrimethamine alone in symptomatic falciparum malaria.一项针对有症状恶性疟原虫疟疾患者的双盲试验，比较了甲氟喹与周效磺胺-乙胺嘧啶固定组合和单独使用周效磺胺-乙胺嘧啶的疗效。
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本文引用的文献

1
Treatment of falciparum malaria from Vietnam with a phenanthrene methanol (WR 33063) and a quinoline methanol (WR 30090).用一种菲甲醇（WR 33063）和一种喹啉甲醇（WR 30090）治疗来自越南的恶性疟。
Antimicrob Agents Chemother. 1973 Feb;3(2):224-7. doi: 10.1128/AAC.3.2.224.
2
A review of the drug sensitivity of Plasmodium falciparum in Thailand.泰国恶性疟原虫药物敏感性综述。
Southeast Asian J Trop Med Public Health. 1972 Jun;3(2):190-7.
3
Mefloquine (WR 142,490) in the treatment of human malaria.甲氟喹（WR 142,490）用于治疗人类疟疾。
Science. 1975 Nov 21;190(4216):792-4. doi: 10.1126/science.1105787.