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柠檬醛、水飞蓟宾和百里醌对甲氨蝶呤诱导的大鼠肺损伤的保护作用评估

Evaluation of the Protective Effect of Citral, Silymarin, and Thymoquinone on Methotrexate-Induced Lung Injury in Rats.

作者信息

Sakineh Amani, Noorbakhsh Mohammad Foad, Ahmadi Nasrollah, Saeed Nazifi, Behdokht Barzan

机构信息

Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

出版信息

J Pharmacopuncture. 2023 Jun 30;26(2):184-191. doi: 10.3831/KPI.2023.26.2.184.

DOI:10.3831/KPI.2023.26.2.184
PMID:37405117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10315881/
Abstract

OBJECTIVES

Several studies have reported that methotrexate is an anti-cancer and immunosuppressive drug leading to lung injury. Therefore, the present study aimed to investigate the protective effects of silymarin, citral, and thymoquinone on methotrexate-induced pulmonary toxicity.

METHODS

Forty-eight rats were divided into six groups, including healthy, Methotrexate, and drug carrier control groups and silymarin, citral, and thymoquinone treatment groups. At the end of the experiment, the studied rats were anesthetized and sacrificed by CO. Lung tissue samples were isolated to measure the antioxidant activity and histopathological evaluation.

RESULTS

In the thymoquinone treatment group, the concentration of total antioxidant capacity and Malondialdehyde increased and decreased significantly, respectively, compared to the methotrexate group. The histopathological evaluation of the lung of the methotrexate group showed hemorrhage and congestion, the nodule-like accumulation of mononuclear inflammatory lymphocytes around the blood vessel, a small number of neutrophils around the blood vessel, and the inflammatory cells around the small vessels. However, no significant pathological alterations were observed in the treatment groups, especially the thymoquinone treatment group.

CONCLUSION

Thymoquinone has the greatest protective effect on methotrexate-induced lung injury, probably due to its antioxidant effect.

摘要

目的

多项研究报道甲氨蝶呤是一种可导致肺损伤的抗癌和免疫抑制药物。因此，本研究旨在探讨水飞蓟宾、柠檬醛和百里醌对甲氨蝶呤诱导的肺毒性的保护作用。

方法

将48只大鼠分为六组，包括健康组、甲氨蝶呤组、药物载体对照组以及水飞蓟宾、柠檬醛和百里醌治疗组。实验结束时，对研究的大鼠进行麻醉并通过CO处死。分离肺组织样本以测量抗氧化活性并进行组织病理学评估。

结果

与甲氨蝶呤组相比，百里醌治疗组的总抗氧化能力浓度显著升高，丙二醛浓度显著降低。甲氨蝶呤组肺组织病理学评估显示出血和充血，血管周围有结节状单核炎性淋巴细胞聚集，血管周围有少量中性粒细胞，小血管周围有炎性细胞。然而，治疗组尤其是百里醌治疗组未观察到明显的病理改变。

结论

百里醌对甲氨蝶呤诱导的肺损伤具有最大的保护作用，可能是由于其抗氧化作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/f2b97424ef84/jop-26-2-184-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/8d4948405907/jop-26-2-184-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/98d95088b200/jop-26-2-184-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/03e22e8809ae/jop-26-2-184-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/ff8ca16d2b37/jop-26-2-184-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/1016e57107e6/jop-26-2-184-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/d87c53dcf443/jop-26-2-184-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/f2b97424ef84/jop-26-2-184-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/8d4948405907/jop-26-2-184-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/98d95088b200/jop-26-2-184-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/03e22e8809ae/jop-26-2-184-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/ff8ca16d2b37/jop-26-2-184-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/1016e57107e6/jop-26-2-184-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/d87c53dcf443/jop-26-2-184-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0086/10315881/f2b97424ef84/jop-26-2-184-f7.jpg

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