鉴定S-1,2-二氯乙烯基-N-乙酰半胱氨酸为三氯乙烯的一种尿代谢物：对其在雄性大鼠中肾致癌性的一种可能解释。 - Suppr

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超能文献

Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.

作者信息

Dekant W, Metzler M, Henschler D

出版信息

Biochem Pharmacol. 1986 Aug 1;35(15):2455-8. doi: 10.1016/0006-2952(86)90039-0.

DOI:10.1016/0006-2952(86)90039-0

PMID:3741453

Abstract

摘要

相似文献

Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.鉴定S-1,2-二氯乙烯基-N-乙酰半胱氨酸为三氯乙烯的一种尿代谢物：对其在雄性大鼠中肾致癌性的一种可能解释。

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Metabolism of trichloroethene--in vivo and in vitro evidence for activation by glutathione conjugation.三氯乙烯的代谢——体内和体外实验中谷胱甘肽结合导致激活的证据

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Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity.

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Identification of N-acetyl(2,2-dichlorovinyl)- and N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in the rat.鉴定N-乙酰基（2,2-二氯乙烯基）-和N-乙酰基（1,2-二氯乙烯基）-L-半胱氨酸为大鼠体内三氯乙烯的两种区域异构体巯基尿酸。

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Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene.鉴定 N-乙酰-S-(1,2-二氯乙烯基)-L-半胱氨酸亚砜的化学反应活性和肾毒性，N-乙酰-S-(1,2-二氯乙烯基)-L-半胱氨酸亚砜是三氯乙烯的一种潜在反应性代谢物。

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Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.两种区域异构体硫醚氨酸及三氯乙烯半胱氨酸S-共轭物的致突变性和细胞毒性。

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Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure.具有肾毒性和基因毒性的N-乙酰-S-二氯乙烯基-L-半胱氨酸是人类职业性接触1,1,2-三氯乙烯后的一种尿液代谢产物：对三氯乙烯接触风险的影响。

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Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway.三氯乙烯的代谢与动力学及其与毒性和致癌性的关系。硫醚氨酸途径的相关性。

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引用本文的文献

Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.三氯乙烯的生物转化及其在致突变性、致癌性和靶器官毒性中的作用。

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Metabolism and tissue distribution of orally administered trichloroethylene in male and female rats: identification of glutathione- and cytochrome P-450-derived metabolites in liver, kidney, blood, and urine.雄性和雌性大鼠口服三氯乙烯后的代谢及组织分布：肝脏、肾脏、血液和尿液中谷胱甘肽及细胞色素P-450衍生代谢物的鉴定

J Toxicol Environ Health A. 2006 Jul;69(13):1285-309. doi: 10.1080/15287390500360133.

Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate.三氯乙烯及其代谢产物三氯乙酸和二氯乙酸诱导肝肿瘤的作用模式。

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Metabolism of trichloroethylene.三氯乙烯的代谢

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Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine.在体内和体外应用S-(1,2-二氯乙烯基)-L-半胱氨酸和S-(2,2-二氯乙烯基)-L-半胱氨酸后，离体灌注大鼠肾脏系统中肾功能的改变。

Arch Toxicol. 1996;70(3-4):224-9. doi: 10.1007/s002040050264.

Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture.三氯乙烯、四氯乙烯及其四种代谢产物对大鼠全胚胎培养的发育毒性

Arch Toxicol. 1995;70(2):71-82. doi: 10.1007/BF02733666.

Studies on the comparative toxicity of S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2-dichlorovinyl)-L-homocysteine and 1,1,2-trichloro-3,3,3-trifluoro-1-propene in the Fischer 344 rat.S-(1,2-二氯乙烯基)-L-半胱氨酸、S-(1,2-二氯乙烯基)-L-高半胱氨酸和1,1,2-三氯-3,3,3-三氟-1-丙烯对费希尔344大鼠的比较毒性研究。

Arch Toxicol. 1994;69(2):99-110. doi: 10.1007/s002040050144.

Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene.

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Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine.具有细胞毒性和肾毒性的S-共轭物S-(2-氯-1,1,2-三氟乙基)-L-半胱氨酸的生物活化机制

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Induction of unscheduled DNA synthesis and micronucleus formation in Syrian hamster embryo fibroblasts treated with cysteine S-conjugates of chlorinated hydrocarbons.用氯代烃的半胱氨酸 S-共轭物处理叙利亚仓鼠胚胎成纤维细胞后非定标性 DNA 合成及微核形成的诱导作用

Cell Biol Toxicol. 1988 Dec;4(4):393-403. doi: 10.1007/BF00117768.

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