人工智能拯救电压成像。
AI to the rescue of voltage imaging.
机构信息
Allen Institute, MindScope program, Seattle, USA.
Allen Institute, Neural Dynamics program, Seattle, USA.
出版信息
Cell Rep Methods. 2023 Jun 16;3(6):100505. doi: 10.1016/j.crmeth.2023.100505. eCollection 2023 Jun 26.
Abstract
In a recent issue of , Platisa et al. present an approach for long-term, population voltage imaging with single spike resolution across a local population of 100 neurons. Key to this step forward was the combination of a customized high-speed two-photon microscope with an optimized, positive-going, genetically encoded voltage indicator and a tailored machine learning denoising algorithm.
摘要
在最近一期的《》中，Platisa 等人提出了一种新方法，可实现 100 个神经元局部群体的单尖峰分辨率的长期、群体电压成像。这一进展的关键是将定制的高速双光子显微镜与优化的、正向的、基因编码的电压指示剂以及定制的机器学习去噪算法相结合。
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