Department of Periodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
BMC Oral Health. 2023 Jul 11;23(1):473. doi: 10.1186/s12903-023-03208-3.
The presence of comorbidities, especially those with a chronic inflammatory nature such as periodontitis, can facilitate COVID-19 progression toward more severe forms. Both of these diseases can affect systemic health and alter hematological test results. In this study, we decided to investigate COVID-19 and periodontitis' possible interaction with these alterations.
Hospitalized patients with a definitive diagnosis of COVID-19 were included. Controls had mild to moderate COVID-19, while cases had severe to critical COVID-19. Periodontal examination was done for each patient. Relevant medical and hematological data were extracted from patient's hospital files.
A total of 122 patients entered the final analysis. The minimum white blood cell counts were associated with the severity of periodontitis. The interaction between periodontitis and COVID-19 was associated with increased minimum white blood cell counts and decreased platelet counts. COVID-19 severity was associated with increased venous oxygen saturation, prothrombin time, the maximum partial thromboplastin time, the maximum and average urea, the maximum creatinine, the maximum potassium, and lactate dehydrogenase, and decreased sodium levels.
Results of this study showed that several blood parameters were associated with periodontitis, COVID-19, or the interaction between them.
合并症的存在，特别是那些具有慢性炎症性质的合并症，如牙周炎，可以促进 COVID-19 向更严重的形式发展。这两种疾病都会影响全身健康并改变血液测试结果。在这项研究中，我们决定研究 COVID-19 和牙周炎与这些变化的可能相互作用。
纳入了明确诊断为 COVID-19 的住院患者。对照组患者的 COVID-19 为轻度至中度，而病例组患者的 COVID-19 为重度至危重度。对每位患者进行牙周检查。从患者的病历中提取相关的医疗和血液数据。
共有 122 名患者进入最终分析。白细胞计数最低与牙周炎的严重程度有关。牙周炎和 COVID-19 之间的相互作用与最低白细胞计数增加和血小板计数减少有关。COVID-19 严重程度与静脉血氧饱和度、凝血酶原时间、最大部分凝血活酶时间、最大和平均尿素、最大肌酐、最大钾和乳酸脱氢酶增加以及钠水平降低有关。
本研究结果表明，几个血液参数与牙周炎、COVID-19 或它们之间的相互作用有关。
