沙门氏菌中非特异性酸性磷酸酶的调控：phoN和phoP基因
Regulation of nonspecific acid phosphatase in Salmonella: phoN and phoP genes.
作者信息
Kier L D, Weppelman R M, Ames B N
出版信息
J Bacteriol. 1979 Apr;138(1):155-61. doi: 10.1128/jb.138.1.155-161.1979.
Abstract
Mutations in Salmonella typhimurium strains lacking nonspecific acid phosphatase mapped in two unlinked loci. One of these, phoP, was cotransducible by phage P22 with purB, whereas the second, phoN, was cotransducible by phage P1 with purA. Mutants with temperature-sensitive nonspecific acid phosphatase activity (measured in whole cells) were also isolated. A phoN mutant with thermolabile whole-cell activity was isolated directly from wild-type LT-2. Several other mutants with temperature-sensitive enzyme activity were also isolated as revertants of phoN mutants. These data suggest that phoN might be a structural locus for nonspecific acid phosphatase. The observation that a mutation resulting in high level of nonspecific acid phosphatase mapped in phoP suggests a possible regulatory role for this locus.
摘要
在缺乏非特异性酸性磷酸酶的鼠伤寒沙门氏菌菌株中，突变定位在两个不连锁的基因座上。其中一个基因座phoP可被噬菌体P22与purB共转导，而另一个基因座phoN可被噬菌体P1与purA共转导。还分离出了具有温度敏感性非特异性酸性磷酸酶活性（在全细胞中测量）的突变体。直接从野生型LT-2中分离出了具有热不稳定全细胞活性的phoN突变体。还分离出了其他几个具有温度敏感性酶活性的突变体作为phoN突变体的回复体。这些数据表明phoN可能是非特异性酸性磷酸酶的结构基因座。在phoP中定位到一个导致高水平非特异性酸性磷酸酶的突变，这一观察结果表明该基因座可能具有调控作用。
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