• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微针介导的光热治疗和免疫治疗联合抗肿瘤药物递送系统的构建与应用。

Construction and application of microneedle-mediated photothermal therapy and immunotherapy combined anti-tumor drug delivery system.

机构信息

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, P.R. China.

Institute of Laser Advanced Manufacturing, Zhejiang University of Technology, Hangzhou, Zhejiang, P.R. China.

出版信息

Drug Deliv. 2023 Dec;30(1):2232950. doi: 10.1080/10717544.2023.2232950.

DOI:10.1080/10717544.2023.2232950
PMID:37439010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10348037/
Abstract

Conventional treatments for tumors were frequently accompanied by drawbacks and side effects. It might be useful to use the revolutionary microneedle technology which combines photothermal therapy with tumor immunotherapy. In this study, we created a microneedle drug delivery system with mercapto-modified gold nanorods and immune checkpoint blocker anti-PD-1 polypeptide. With good mechanical strength, the microneedle system can efficiently penetrate the skin and deliver drugs. When inserted into human skin, anti-PD-1 peptides and gold nanorods can be released, boosting the capacity of cytotoxic T lymphocytes to destroy tumor cells. Additionally, the elimination of the tumor is aided by the production of heat while being exposed to near-infrared light. This microneedle drug delivery system can enhance the immunological reaction and prolong the survival time of mice. Moreover, it has been demonstrated that the system has mild toxic and side effects on normal tissues and can effectively inhibit the growth of tumors, indicating a bright prospect for the treatment of cancers.

摘要

肿瘤的传统治疗方法常常伴随着缺点和副作用。利用结合光热疗法和肿瘤免疫疗法的革命性微针技术可能会很有用。在这项研究中，我们创建了一种带有巯基修饰的金纳米棒和免疫检查点阻断剂抗 PD-1 多肽的微针药物递送系统。该微针系统具有良好的机械强度，可以有效地穿透皮肤并输送药物。当插入人体皮肤时，抗 PD-1 肽和金纳米棒可以被释放，增强细胞毒性 T 淋巴细胞破坏肿瘤细胞的能力。此外，在近红外光照射下产生的热量有助于消除肿瘤。这种微针药物递送系统可以增强免疫反应并延长小鼠的生存时间。此外，已经证明该系统对正常组织具有轻微的毒性和副作用，并且可以有效地抑制肿瘤的生长，这表明该系统在癌症治疗方面有广阔的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/31801f363512/IDRD_A_2232950_F0027_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/6db15758714c/IDRD_A_2232950_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/4a3494325b14/IDRD_A_2232950_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/76dd6ecd5414/IDRD_A_2232950_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/74f1876d8e60/IDRD_A_2232950_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/339eaf36e363/IDRD_A_2232950_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/5a4c3facbb7e/IDRD_A_2232950_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/1f144b640bdc/IDRD_A_2232950_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/67648296bca4/IDRD_A_2232950_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/e926c1527a1f/IDRD_A_2232950_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/55744c487f4c/IDRD_A_2232950_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/473b0e5f53c9/IDRD_A_2232950_F0010_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/974acea5cdc5/IDRD_A_2232950_F0011_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/5cdfe0cd1d7e/IDRD_A_2232950_F0012_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/d5f3df9ec044/IDRD_A_2232950_F0013_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/0a08c974540a/IDRD_A_2232950_F0014_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/fbaaf730d2c8/IDRD_A_2232950_F0015_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/58f7d45a3baa/IDRD_A_2232950_F0016_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/b7d223848154/IDRD_A_2232950_F0017_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/fb631c1c5bb8/IDRD_A_2232950_F0018_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/a1d0bf49b0a3/IDRD_A_2232950_F0019_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/76943a7f57ee/IDRD_A_2232950_F0020_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/b8b4310e6705/IDRD_A_2232950_F0021_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/1e20109ec2bd/IDRD_A_2232950_F0022_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/3eb50fe6e544/IDRD_A_2232950_F0023_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/69ef94dd9443/IDRD_A_2232950_F0024_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/ffbe153ce57e/IDRD_A_2232950_F0025_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/782090737aaa/IDRD_A_2232950_F0026_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/31801f363512/IDRD_A_2232950_F0027_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/6db15758714c/IDRD_A_2232950_UF0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/4a3494325b14/IDRD_A_2232950_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/76dd6ecd5414/IDRD_A_2232950_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/74f1876d8e60/IDRD_A_2232950_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/339eaf36e363/IDRD_A_2232950_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/5a4c3facbb7e/IDRD_A_2232950_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/1f144b640bdc/IDRD_A_2232950_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/67648296bca4/IDRD_A_2232950_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/e926c1527a1f/IDRD_A_2232950_F0008_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/55744c487f4c/IDRD_A_2232950_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/473b0e5f53c9/IDRD_A_2232950_F0010_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/974acea5cdc5/IDRD_A_2232950_F0011_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/5cdfe0cd1d7e/IDRD_A_2232950_F0012_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/d5f3df9ec044/IDRD_A_2232950_F0013_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/0a08c974540a/IDRD_A_2232950_F0014_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/fbaaf730d2c8/IDRD_A_2232950_F0015_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/58f7d45a3baa/IDRD_A_2232950_F0016_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/b7d223848154/IDRD_A_2232950_F0017_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/fb631c1c5bb8/IDRD_A_2232950_F0018_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/a1d0bf49b0a3/IDRD_A_2232950_F0019_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/76943a7f57ee/IDRD_A_2232950_F0020_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/b8b4310e6705/IDRD_A_2232950_F0021_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/1e20109ec2bd/IDRD_A_2232950_F0022_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/3eb50fe6e544/IDRD_A_2232950_F0023_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/69ef94dd9443/IDRD_A_2232950_F0024_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/ffbe153ce57e/IDRD_A_2232950_F0025_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/782090737aaa/IDRD_A_2232950_F0026_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a866/10348037/31801f363512/IDRD_A_2232950_F0027_C.jpg

相似文献

1
Construction and application of microneedle-mediated photothermal therapy and immunotherapy combined anti-tumor drug delivery system.微针介导的光热治疗和免疫治疗联合抗肿瘤药物递送系统的构建与应用。
Drug Deliv. 2023 Dec;30(1):2232950. doi: 10.1080/10717544.2023.2232950.
2
Intelligent and spatiotemporal drug release based on multifunctional nanoparticle-integrated dissolving microneedle system for synergetic chemo-photothermal therapy to eradicate melanoma.基于多功能纳米粒子整合溶解微针系统的智能时空药物释放用于协同化光热治疗以根除黑色素瘤。
Acta Biomater. 2021 Nov;135:164-178. doi: 10.1016/j.actbio.2021.09.009. Epub 2021 Sep 13.
3
Construction of a core-shell microneedle system to achieve targeted co-delivery of checkpoint inhibitors for melanoma immunotherapy.构建核壳型微针系统以实现黑色素瘤免疫治疗中检查点抑制剂的靶向共递药。
Acta Biomater. 2020 Mar 1;104:147-157. doi: 10.1016/j.actbio.2019.12.037. Epub 2020 Jan 3.
4
Au Nanocage-Strengthened Dissolving Microneedles for Chemo-Photothermal Combined Therapy of Superficial Skin Tumors.基于金纳米笼增强的溶解微针用于治疗皮肤浅层肿瘤的光热化疗联合治疗
ACS Appl Mater Interfaces. 2018 Mar 21;10(11):9247-9256. doi: 10.1021/acsami.7b18293. Epub 2018 Mar 13.
5
A Dual Functional Drug Delivery System that Combines Photothermal Therapy and Immunotherapy to Treat Tumors.一种结合光热疗法和免疫疗法用于治疗肿瘤的双功能药物递送系统。
Mol Pharm. 2022 May 2;19(5):1449-1457. doi: 10.1021/acs.molpharmaceut.1c00999. Epub 2022 Apr 7.
6
Dissolving Graphene/Poly(Acrylic Acid) Microneedles for Potential Transdermal Drug Delivery and Photothermal Therapy.溶解型石墨烯/聚丙烯酸微针用于潜在的经皮药物传输和光热治疗。
J Nanosci Nanotechnol. 2019 May 1;19(5):2453-2459. doi: 10.1166/jnn.2019.15884.
7
Rationally designed peptide-conjugated gold/platinum nanosystem with active tumor-targeting for enhancing tumor photothermal-immunotherapy.理性设计的肽偶联金/铂纳米系统具有主动肿瘤靶向作用，可增强肿瘤光热免疫治疗。
J Control Release. 2019 Aug 28;308:29-43. doi: 10.1016/j.jconrel.2019.06.031. Epub 2019 Jun 25.
8
Biomimetic black phosphorus quantum dots-based photothermal therapy combined with anti-PD-L1 treatment inhibits recurrence and metastasis in triple-negative breast cancer.基于仿生黑磷量子点的光热治疗联合抗 PD-L1 治疗抑制三阴性乳腺癌的复发和转移。
J Nanobiotechnology. 2021 Jun 13;19(1):181. doi: 10.1186/s12951-021-00932-2.
9
Functionalized biomimetic nanoparticles combining programmed death-1/programmed death-ligand 1 blockade with photothermal ablation for enhanced colorectal cancer immunotherapy.功能化仿生纳米颗粒结合程序性死亡-1/程序性死亡配体-1阻断与光热消融用于增强结直肠癌免疫治疗。
Acta Biomater. 2023 Feb;157:451-466. doi: 10.1016/j.actbio.2022.11.043. Epub 2022 Nov 25.
10
[Drug release system controlled by near infrared light].[近红外光控释药物系统]
Yakugaku Zasshi. 2013;133(3):369-72. doi: 10.1248/yakushi.12-00239-3.

引用本文的文献

1
Advances in mechanisms and challenges in clinical translation of synergistic nanomaterial-based therapies for melanoma.基于纳米材料的黑色素瘤协同疗法的临床转化机制进展与挑战
Front Cell Dev Biol. 2025 Jul 25;13:1648379. doi: 10.3389/fcell.2025.1648379. eCollection 2025.
2
Nanoagent-Mediated Photothermal Therapy: From Delivery System Design to Synergistic Theranostic Applications.纳米制剂介导的光热疗法：从递送系统设计到协同诊疗应用
Int J Nanomedicine. 2025 May 29;20:6891-6927. doi: 10.2147/IJN.S522736. eCollection 2025.
3
Microneedles as a Promising Technology for Disease Monitoring and Drug Delivery: A Review.

本文引用的文献

1
Cold Atmospheric Plasma Activates Selective Photothermal Therapy of Cancer.冷等离体子体激活癌症的选择性光热疗法。
Molecules. 2022 Sep 13;27(18):5941. doi: 10.3390/molecules27185941.
2
Buffet-style Cu(II) for enhance disulfiram-based cancer therapy.布菲式 Cu(II)增强基于双硫仑的癌症疗法。
J Colloid Interface Sci. 2022 Oct 15;624:734-746. doi: 10.1016/j.jcis.2022.06.009. Epub 2022 Jun 6.
3
Recent advances in selective photothermal therapy of tumor.肿瘤的选择性光热治疗的最新进展。
微针：一种用于疾病监测和药物递送的有前景的技术综述
ACS Mater Au. 2024 Nov 28;5(1):115-140. doi: 10.1021/acsmaterialsau.4c00125. eCollection 2025 Jan 8.
4
Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices.揭开微针在药物传递中的作用：原理、观点和实践。
Drug Deliv Transl Res. 2024 Jun;14(6):1393-1431. doi: 10.1007/s13346-023-01475-9. Epub 2023 Nov 30.
J Nanobiotechnology. 2021 Oct 24;19(1):335. doi: 10.1186/s12951-021-01080-3.
4
Selective thermotherapy of tumor by self-regulating photothermal conversion system.肿瘤的自调节光热转换系统选择性热疗。
J Colloid Interface Sci. 2022 Jan;605:752-765. doi: 10.1016/j.jcis.2021.07.134. Epub 2021 Jul 30.
5
Cancer immunotherapy: Pros, cons and beyond.癌症免疫疗法：利弊及其他。
Biomed Pharmacother. 2020 Apr;124:109821. doi: 10.1016/j.biopha.2020.109821. Epub 2020 Jan 18.
6
Microneedle-Assisted Topical Delivery of Photodynamically Active Mesoporous Formulation for Combination Therapy of Deep-Seated Melanoma.微针辅助递药的光动力治疗中深层黑素瘤的介孔制剂联合治疗
ACS Nano. 2018 Dec 26;12(12):11936-11948. doi: 10.1021/acsnano.8b03007. Epub 2018 Nov 16.
7
Microneedle-Mediated Transdermal Delivery of Bevacizumab.微针介导的贝伐单抗经皮递送。
Mol Pharm. 2018 Aug 6;15(8):3545-3556. doi: 10.1021/acs.molpharmaceut.8b00544. Epub 2018 Jul 24.
8
Intradermal Delivery of a Near-Infrared Photosensitizer Using Dissolving Microneedle Arrays.使用溶解微针阵列进行近红外光敏剂的皮内递送。
J Pharm Sci. 2018 Sep;107(9):2439-2450. doi: 10.1016/j.xphs.2018.05.017. Epub 2018 Jun 1.
9
Transdermal immunomodulation: Principles, advances and perspectives.经皮免疫调节：原理、进展与展望。
Adv Drug Deliv Rev. 2018 Mar 1;127:3-19. doi: 10.1016/j.addr.2018.03.010. Epub 2018 Mar 29.
10
De-novo and acquired resistance to immune checkpoint targeting.免疫检查点靶向治疗的获得性和新生耐药性。
Lancet Oncol. 2017 Dec;18(12):e731-e741. doi: 10.1016/S1470-2045(17)30607-1.