利用神经营养 bHLH 转录因子诱导神经胶质细胞的神经再生。
Inducing Neural Regeneration from Glia Using Proneural bHLH Transcription Factors.
机构信息
Department of Biological Structure, University of Washington, Seattle, WA, USA.
出版信息
Adv Exp Med Biol. 2023;1415:577-582. doi: 10.1007/978-3-031-27681-1_84.
PMID:37440089
Abstract
Endogenous regeneration strategies to replace lost neurons hold great promise for treating neurodegenerative disorders. In the majority of cases, neural regeneration is induced by converting resident glial cells into neurogenic precursors. This review will outline how proneural bHLH transcription factors can be used to reprogram glia in the brain and retina into a source for new neurons.
摘要
内源性再生策略有望替代丢失的神经元，为治疗神经退行性疾病带来新希望。在大多数情况下，神经再生是通过将神经胶质细胞转化为神经前体细胞来诱导的。本文将概述如何利用原神经 bHLH 转录因子将大脑和视网膜中的神经胶质细胞重编程为新神经元的来源。
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