Ademuyiwa Oluwaseun Hannah, Fasogbon Beatrice Mofoluwaso, Bamidele Oluwaseun Peter, Ukpo Grace Eigbibhalu
Department of Food Technology, Federal Institute of Industrial Research, Lagos, Nigeria.
Department of Food Science and Technology, University of Venda, Limpopo Province, South Africa.
Heliyon. 2023 Jun 16;9(6):e17379. doi: 10.1016/j.heliyon.2023.e17379. eCollection 2023 Jun.
Cardiovascular disease is one of the leading killers in the world today, and hyperlipidemia is one of the main risk factors. The prevalence of hyperlipidemia is rising dramatically worldwide and is mostly felt in poorer nations. The majority of communities and individuals in Africa are known to turn to ethnomedicine for their medical requirements. The tropical plant , which is grown for its edible, ripe fruit in Africa, was used in folk medicine for treatment of cardiovascular issues as well as a number of serious illnesses. This study assessed the anticholesterolemic property of the ethanolic extracts of leaves, adapting the egg yolk-induced hyperlipidaemia model in Wistar albino rats. This study prepared egg yolk to induce hyperlipidaemia in the Wistar rats, then treated some groups with the extract of leaves, and other groups with the standard drug Fenofibrate. The Wistar rats in the control group were given 2% acacia instead of egg yolk. The total cholesterol, triglycerides, as well as biological and haematological parameters, were determined. The leaves extracts significantly () decreased the total cholesterol and LDL cholesterol levels at all doses administered, but the extract and the standard drug had no significant effect on HDL cholesterol. An inverse relationship between the leaves extract doses and the cholesterol levels was observed placing the efficacy in the order of 100 mg/kg > 250 mg/kg > Fenofibrate (2.29 mg/kg) > 500 mg/kg. With the potential efficacy of leaves extract in the treatment of hypercholesterolemia and, as a result, cardiovascular diseases, more research on bioactive molecule isolation/characterisation for pharmaceutical use or incorporation into functional food products for CVD management is required.
心血管疾病是当今世界主要的杀手之一，而高脂血症是主要风险因素之一。高脂血症在全球的患病率正在急剧上升，且在较贫穷国家更为普遍。众所周知，非洲的大多数社区和个人会求助于民族医学来满足他们的医疗需求。这种在非洲因其可食用的成熟果实而种植的热带植物，在民间医学中被用于治疗心血管问题以及多种严重疾病。本研究采用Wistar白化大鼠蛋黄诱导的高脂血症模型，评估了该植物叶乙醇提取物的抗胆固醇特性。本研究制备蛋黄以诱导Wistar大鼠发生高脂血症，然后用该植物叶提取物处理一些组，用标准药物非诺贝特处理其他组。对照组的Wistar大鼠给予2%阿拉伯胶而非蛋黄。测定了总胆固醇、甘油三酯以及生物学和血液学参数。该植物叶提取物在所有给药剂量下均显著（）降低了总胆固醇和低密度脂蛋白胆固醇水平，但提取物和标准药物对高密度脂蛋白胆固醇无显著影响。观察到该植物叶提取物剂量与胆固醇水平呈负相关，其疗效顺序为100mg/kg > 250mg/kg > 非诺贝特（2.29mg/kg）> 500mg/kg。鉴于该植物叶提取物在治疗高胆固醇血症以及心血管疾病方面的潜在疗效，需要对用于制药用途的生物活性分子分离/表征或纳入用于心血管疾病管理的功能性食品进行更多研究。
